Gene interactions and pathways from curated databases and text-mining

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BBC3 — TNF

Text-mined interactions from Literome

Wang et al., Cell Death Differ 2009 : In this study, we found that p53 upregulated modulator of apoptosis ( PUMA ), a p53 downstream target and a BH3-only Bcl-2 family member, is directly regulated by NF-kappaB in response to TNF-alpha
Pastor et al., Dis Colon Rectum 2010 (Colorectal Neoplasms) : The purpose of the current study was to evaluate the effects of tumor necrosis factor alpha (TNF-alpha) on p53 and p53 up-regulated modulator of apoptosis ( PUMA ), a downstream effector of p53 in the apoptotic pathway in colorectal cancer cells
Omori et al., Diabetologia 2011 : TNF-a alone did not induce beta cell death, but did abrogate preproinsulin precursor mRNA synthesis in response to high glucose stimulation, which was inversely associated with upregulation of BBC3 mRNA expression by TNF-a