Finan et al., Lung Cancer 2006
(Genetic Predisposition to Disease) :
Overexpression of TIMP-3 resulted in apoptosis of A549 lung cancer cells and AdCMVTIMP3 up-regulated the expression of p53, Fas ligand , TNFR1 and TNFR2 on these cells
Yuan et al., Amino Acids 2008
(MAP Kinase Signaling System) :
TIMP-3 treatment induced the expression of Fas and Fasl proteins, and the activation of caspase-8 and caspase-3