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EPHB2 — STAT1
Text-mined interactions from Literome
Marra et al., Hepatology 1999
(Drug-Induced Liver Injury...) :
In the
presence of the
ERK inhibitor, binding of the AP-1 complex and of
STAT1 to the related regulatory elements was inhibited
Zhang et al., Carcinogenesis 2004
:
In vitro kinase assays using the combined STAT1 proteins as substrates from immunoprecipitation and glutathione S-transferase pull down show that active
ERK1 , JNK1, p38 kinase, MEK1 and MSK1
stimulated phosphorylation of
STAT1 ( Ser727 ) indirectly through an unidentified factor or a downstream kinase
Nowroozi et al., Hum Mol Genet 2005
(Thanatophoric Dysplasia) :
Using PC12 cell lines stably expressing inducible mutant receptors containing the TDII mutation, K650E, sustained activation of
ERK1/2 and
activation of
STAT1 and STAT3, but not STAT5, is observed in the absence of ligand ... Silencing of
STAT1 or 3 independently or in combination
had no significant effect on ligand independent neurite outgrowth,
ERK1/2 activation or p21 ( WAF1/CIP1 ) protein levels
Sharma-Walia et al., J Virol 2005
(Herpesviridae Infections...) :
Several MAPK regulated host transcription factors such as c-Jun, STAT1alpha, MEF2, c-Myc, ATF-2 and c-Fos were induced early during infection, and
ERK inhibition significantly
blocked the c-Fos, c-Jun, c-Myc, and
STAT1alpha activation in the infected cells
Soond et al., J Biol Chem 2008
:
Moreover, silencing betaTRCP expression or pharmacological inhibition of
ERK activity
stabilized STAT1 expression
Benco et al., Reproduction 2009
:
Overexpression of
STAT1 reversed the effect of ghrelin on STAT1, PCNA, PGF, OXT ( from stimulatory to inhibitory ), BCL2, P ( 4 ) ( from inhibitory to stimulatory ), prevented ghrelin effect on caspase-3 and BAX, but did not
affect ghrelin 's effect on
MAPK/ERK1,2 expression
Zhao et al., Cell Mol Biol Incl Cyto Enzymol 2009
:
U0126 induced up-regulation of ERK1/2 and down-regulation of phosphorylated
ERK1/2 , increased STAT1 and STAT2 expression in a dose dependent manner, and
activated STAT1/2 via their phosphorylation
Chung et al., J Pharmacol Sci 2010
(Inflammation) :
In conclusion, this study proposes an anti-inflammatory mechanism of alpha-viniferin, down regulating STAT-1-inducible inflammatory genes via inhibiting
ERK mediated
STAT-1 activation in IFN-gamma stimulated macrophages
Li et al., J Immunol 2010
(Atherosclerosis) :
In this study, we demonstrate that the IFN-gamma mediated phosphorylation of
STAT1 on Ser ( 727 ), crucial for its maximal activity, was
attenuated in human macrophages by pharmacological inhibition of
ERK
Wang et al., Biochem Biophys Res Commun 2012
(Carcinoma, Hepatocellular...) :
Moreover, sorafenib inhibited IFN-a induced oncogenic signaling of STAT3, AKT and
ERK but not the
activation of the tumor suppressor
STAT1
Oguro et al., Eur J Cancer 2013
(Carcinoma, Renal Cell...) :
Western blot analysis revealed that the tocilizumab enhanced the interferon induced phosphorylation of
STAT1 and
inhibited SOCS3 expression and the phosphorylation of both STAT3 and
ERK
Fang et al., PloS one 2013
(Leukemia, Myeloid, Acute...) :
MEK inhibitors PD98059 and U0216 not only inhibited the phosphorylation of STAT1, but also abrogated dasatinib induced myeloid differentiation, suggesting that
MEK/ERK dependent phosphorylation of
STAT1 might be indispensable for the differentiating effect of dasatinib in AML cells
Megeney et al., Dev Genet 1996
:
In differentiated myotubes, LIF treatment resulted in the tyrosine phosphorylation of both STAT3 and STAT1, but
ERK phosphorylation was not detectable, and bFGF treatment did not
lead to
STAT1 or STAT3 tyrosine phosphorylation