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EGF — RHOA

Text-mined interactions from Literome

Kusama et al., Gastroenterology 2002 (Adenocarcinoma...) : Treatment of ASPC-1 cells with fluvastatin markedly attenuated the EGF induced translocation of RhoA from the cytosol to the membrane fraction and caused cell rounding
Kusama et al., Cancer Sci 2006 (Neoplasm Invasiveness...) : Epidermal growth factor (EGF) induced activation of RhoA , as well as RhoB and RhoC, to a lesser extent, was significantly inhibited in p190-RhoA chimera transfected AsPC-1 cells compared with that of control cells ( mock infected ), when assessed by pull-down assay for GTP bound RhoA, RhoB, and RhoC, respectively
Eichorst et al., PloS one 2008 : The results revealed that the EGF induced reduction of RhoA activity in migratory HeLa cells is significantly less than that in stationary cells
Kim et al., Small 2009 : The results reveal that epidermal growth factor (EGF) induces a decrease of RhoA and an increase of Src activities with biphasic time courses in RMCs
Ma et al., Chin J Cancer 2009 (Breast Neoplasms) : Stimulation of EGF triggered RhoA phosphorylation in MDA-MB-231 cells which reached the maximum at 30 min ; RhoA expression did not change ; Ezrin expression was enhanced and reached the maximum at 24 h
Han et al., Endocrinology 2010 : EGF ( 1 ng/ml ) activates RhoA and RhoC, but not RhoB, through elevated protein levels and activity
Kakiashvili et al., J Biol Chem 2011 (MAP Kinase Signaling System) : Surprisingly, TNF-a induced ERK and RhoA stimulation in tubular cells were prevented by epidermal growth factor receptor (EGFR) inhibition or silencing ... Moreover, EGF induced RhoA activation was prevented by GEF-H1 silencing, indicating that GEF-H1 is a key downstream effector of the EGFR
Nakashima et al., Molecular cancer 2011 (Carcinoma...) : EGF induced RhoA activity, as well as the phosphorylation of cofilin and myosin light chain ( MLC ), both targets of ROCK signaling, and Y27632 suppressed both of these processes, indicating that the phosphorylation of cofilin and MLC by EGF occurs through ROCK in Panc1 cells
Casteel et al., J Biol Chem 2012 (Breast Neoplasms) : Co-immunoprecipitation of IQGAP1 with endogenous RhoA/C was enhanced when RhoA/C were activated by epidermal growth factor (EGF) or transfection of a constitutively active guanine nucleotide exchange factor (GEF)
Boscher et al., Mol Biol Cell 2013 (Breast Neoplasms...) : Similarly, caveolin-1/galectin-3 dependent EGF signaling induces motility, peripheral actin ruffling, and RhoA activation in MDA-MB-231 human breast carcinoma cells, but not HeLa cells
Na et al., BMC microbiology 2013 : The recruited CFP-RhoA on the PVM could not be activated by epithelial growth factor (EGF) and no translocation was observed, unlike the unassociated RhoA in the host cell cytosol that migrated to the cell membrane towards the EGF activation spot