Gene interactions and pathways from curated databases and text-mining

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CAV1 — STAT3

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Huang et al., Am J Physiol Lung Cell Mol Physiol 2008 (Hypertension, Pulmonary...) : To evaluate the role of caveolin-1 , PY-STAT3 activation , and superoxide in PAH, MCT injected rats were treated daily with pyrrolidine dithiocarbamate ( PDTC ; starting on days 1, 3, and 14 x 2 wk ), an inhibitor of inflammation and NF-kappaB activation ... Thus the disruption of endothelial cell membrane integrity resulting in caveolin-1 loss and reciprocal activation of PY-STAT3 plays a key role in the MCT induced PAH
Takizawa et al., Biomed Res 2013 (Inflammation...) : Cav-1 induced phosphorylation of JNK and ERK, but not Stat3 in HGFs