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LEP — NUP43

Text-mined interactions from Literome

Hardwick et al., Gastroenterology 2001 (Adenocarcinoma...) : Stimulation with leptin leads to phosphorylation of p42/44 mitogen activated protein kinase and increases proliferation in vitro and in vivo
Dreyer et al., Biochem J 2003 : We now demonstrate that the activation of the IL-1Ra promoter by leptin is strictly dependent on the presence of the long form of the leptin receptor ( OB-Rb ), and that it also requires the activation of the p42/44 mitogen activated protein kinases ( MAPKs ) as well as the presence of a nuclear factor kappaB (NF-kappa B)/PU.1 composite site at position -80 of the IL-1Ra promoter
Maccarrone et al., J Biol Chem 2003 : Leptin binding to the receptor triggered activation of STAT3 but not STAT1 or STAT5 or the mitogen activated protein kinases p38, p42 , and p44
Rouet-Benzineb et al., J Biol Chem 2004 (Colonic Neoplasms) : This study shows that leptin induced a rapid phosphorylation of p42/44 mitogen activated protein kinase, an enhancement of both NF-kappaB DNA binding and transcriptional activities, and a concentration dependent increase of HT-29 cell proliferation
Lang et al., Biochem Biophys Res Commun 2004 : In the same condition, however, leptin per se did not increase phospho-STAT 3 and phospho-p44/42 MAP kinase levels
Dixon et al., J Cardiovasc Pharmacol 2009 (Myocardial Infarction...) : Leptin increased p44 and p42 phosphorylation in Wistar rat hearts by 103.9 % ( P < 0.05 ) and 157.3 % ( P < 0.001 ), respectively, and by 97.0 % ( P < 0.05 ) and 158.1 % ( P < 0.05 ) in hearts from Zucker lean rats
Thompson et al., HPB (Oxford) 2011 (Carcinoma, Hepatocellular...) : Immunoblot analysis demonstrated that leptin significantly activated p42/p44-MAPK , p38-MAPK and STAT3 signalling in a time dependent manner