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IFI27 — RET
Text-mined interactions from Literome
Joshi et al., Oncogene 2007
(Adrenal Gland Neoplasms...) :
This suggests that p18 and p27 functionally collaborate in suppression of tumorigenesis, that loss of both is critical in the development of MEN tumors and that both p18 and
p27 are
regulated by
RET ... Mechanistically,
RET2A represses
p18/p27 mRNA levels while elevating cyclin D1 mRNA levels ...
RET2A mediated regulation of p18 and
p27 , but not of cyclins D1 and D2, requires functional mitogen activated protein kinase signaling
Motti et al., Cell cycle (Georgetown, Tex.) 2007
(MAP Kinase Signaling System...) :
In vitro studies with cellular models of human thyroid carcinoma cells demonstrated that the adoptive expression of oncogenic
RET/PTC1 , Ha-RASV12 or BRAFV600E enhances Skp2 and
reduces p27 protein expression in a MAP kinase dependent manner ; that RAS/BRAF/MAP kinase dependent control of p27 expression in thyroid cancer cells occurs by regulating the stability of Skp2 and p27 protein ; and that antisense oligonucleotides to p27 suppress growth arrest induced by MEK inhibitors