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CAPN15 — NEFH
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Strong et al., J Neurol Sci 1999
(Amyotrophic Lateral Sclerosis) :
We observed no differences between control and ALS in the characteristics of NFH, including migration patterns on 2D-IEF, sensitivity to E. coli, alkaline phosphatase mediated dephosphorylation, peptide mapping, or proteolysis ( calpain,
calpain/calmodulin mediated , phosphorylated or dephosphorylated
NFH )
Gupta et al., Biochem Pharmacol 1997
:
The transient decrease in
NF-H and NF-L axonal transport rate, and recovery correlated in a temporal manner with the previously reported increase of Ca2+/calmodulin dependent protein kinase
mediated phosphorylation of neurofilament proteins and inhibition of
calpain activity in the sciatic nerve in OPIDN