Le et al., Mol Endocrinol 2002
(Liver Neoplasms, Experimental) :
The L973R/A975D mutation abolishes the ability of the IR to induce Stat5 activation, whereas IRS-1 phosphorylation is unaffected
Wang et al., Mol Endocrinol 2009
:
We previously reported that IRS-1 and Janus kinase 2 associate independently of tyrosine phosphorylation via IRS-1 's N terminus and that IRS-1 reconstitution greatly enhances GH-induced ERK, but not STAT5 , activation
Britschgi et al., Cancer Cell 2012
(Breast Neoplasms...) :
Mechanistically, PI3K/mTOR inhibition increased IRS1 dependent activation of JAK2/STAT5 and secretion of IL-8 in several cell lines and primary breast tumors