◀ Back to MMP13

DDR2 — MMP13

Text-mined interactions from Literome

Xu et al., J Biol Chem 2005 (Osteoarthritis, Knee) : Activation of the discoidin domain receptor 2 induces expression of matrix metalloproteinase 13 associated with osteoarthritis in mice ... The DDR2 induced expression of MMP-13 appears to be specific, since we did not observe induction of MMP-1, MMP-3, MMP-8, ADAMTS-4, ADAMTS-5, and IL-1 transcripts in human chondrocytes or Mmp-3, Mmp-8, Adamts-4, Adamts-5, and Il-1 in mouse chondrocytes ... The specific induction of MMP-13 by DDR2 in response to its cartilage-specific ligand, type II collagen, may contribute to cartilage damage in hereditary OA
Su et al., Mol Cell Biochem 2009 (Arthritis, Rheumatoid) : However, the functional role of DDR2 in the regulation of MMP-13 production in synovial fibroblasts has not been elucidated ... Furthermore, stable overexpression of wild type DDR2 in murine synoviocytes dramatically augments the production of MMP-13 ... The activation of DDR2 also mediates the up-regulation of MMP-13 promoter activity in 293T cells ... Inhibitor specific for extracellular signal regulated kinase mitogen activated protein kinase ( ERK MAPK ) cascade was shown to decrease MMP-13 level induced by collagen II in RA synovial fibroblasts and DDR2 induced MMP-13 promoter activity ... The data in this study suggest that DDR2 mediated MMP-13 induction by collagen matrix in synovial fibroblasts of RA contributed to articular cartilage destruction
Xu et al., Am J Pathol 2011 (Osteoarthritis, Knee) : However, the increased DDR2 did not induce MMP-13 expression