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SRC — TRAF6

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SRC — TRAF6 (direct interaction, pull down) Liu et al., J Biol Chem 2012*
• IRef Biogrid Interaction: SRC — TRAF6 (physical association, affinity chromatography technology) Wong et al., Mol Cell 1999
• MIPS CORUM TNFRSF11A-TRAF6-SRC complex: TNFRSF11A-TRAF6-SRC complex complex (SRC-TNFRSF11A-TRAF6) Wong et al., Mol Cell 1999
• IRef Corum Interaction: Complex of SRC-TRAF6-TNFRSF11A (association, anti tag coimmunoprecipitation) Wong et al., Mol Cell 1999
• IRef Hprd Interaction: Complex of 19 proteins (in vivo) Wong et al., Mol Cell 1999
• IRef Hprd Interaction: SRC — TRAF6 (in vivo) Wong et al., Mol Cell 1999
• IRef Ophid Interaction: SRC — TRAF6 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Wong et al., Mol Cell 1999 : TRAF6 , in turn, enhances the kinase activity of c-Src leading to tyrosine phosphorylation of downstream signaling molecules such as c-Cbl
Lee et al., Biochem Biophys Res Commun 2003 (MAP Kinase Signaling System) : The RANK signaling mechanisms involved in these responses include the recruitment of TNF receptor associated factor proteins, the activation of transcription factors ( NF-kappaB, AP-1, and NFAT2 ), the cascades of mitogen activated protein kinases ( ERK, JNK, and p38 ), and the induction of Src- and phosphatidylinositol 3-kinase dependent Akt activation
Wang et al., J Cell Sci 2006 : TRAF6 activation of PI 3-kinase dependent cytoskeletal changes is cooperative with Ras and is mediated by an interaction with cytoplasmic Src