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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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GAB2 — RAC1

Text-mined interactions from Literome

Yu et al., J Biol Chem 2006 : By analyzing Gab2 ( -/- ) mast cells, we find that Gab2 is required for SCF evoked proliferation, activation of Rac/JNK , and Ras ... By re-expressing Gab2 or a Gab2 mutant that can not bind Shp-2 in Gab2 ( -/- ) mast cells or acutely by deleting Shp-2 in mast cells, we found that Gab2 requires Shp-2 for SCF evoked Rac/JNK , Ras activation, and mast cell proliferation
Herrera Abreu et al., Mol Biol Cell 2011 (Breast Neoplasms...) : Expression of either Gab2 or Gab2 ( 2xA ) led to decreased activation of RhoA, but only the latter increased levels of Rac-GTP