◀ Back to RAC1
GAB2 — RAC1
Text-mined interactions from Literome
Yu et al., J Biol Chem 2006
:
By analyzing Gab2 ( -/- ) mast cells, we find that
Gab2 is
required for SCF evoked proliferation, activation of
Rac/JNK , and Ras ... By re-expressing Gab2 or a Gab2 mutant that can not bind Shp-2 in Gab2 ( -/- ) mast cells or acutely by deleting Shp-2 in mast cells, we found that
Gab2 requires Shp-2 for SCF evoked
Rac/JNK , Ras activation, and mast cell proliferation
Herrera Abreu et al., Mol Biol Cell 2011
(Breast Neoplasms...) :
Expression of either
Gab2 or Gab2 ( 2xA ) led to decreased activation of RhoA, but only the latter
increased levels of
Rac-GTP