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MAP3K11 — TNF

Text-mined interactions from Literome

Sathyanarayana et al., Mol Cell 2002 : In addition, TNF-alpha also activates MLK3 and evidently leads to JNK activation in vivo
Zhang et al., J Biol Chem 2004 : Furthermore, tumor necrosis factor alpha induced activation of MLK3 and JNK in MCF-7 cells is blocked by geldanamycin treatment
Korchnak et al., Cell Signal 2009 : MLK3 is required for optimal activation of stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) signaling by TNF , however, the mechanism by which MLK3 is recruited and activated by the TNF receptor remains poorly understood ... Here we report that both TNF and interleukin-1 beta (IL-1 beta) stimulation rapidly activate MLK3 kinase activity
Sondarva et al., Cell Res 2010 : TRAF2-MLK3 interaction is essential for TNF-alpha induced MLK3 activation ... The mechanism by which TNF-alpha activates MLK3 is still not known ... Hence, our data show that the direct interaction between TRAF2 and MLK3 is required for TNF-alpha induced activation of MLK3 and its downstream target, JNK