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FOXC2 — INS

Text-mined interactions from Literome

Grønning et al., Mol Endocrinol 2002 : Insulin and TNF alpha induce expression of the forkhead transcription factor gene Foxc2 in 3T3-L1 adipocytes via PI3K and ERK 1/2 dependent pathways ... At the protein level, immunoblots with Foxc2 antibody demonstrated an induction of Foxc2 by insulin and TNF alpha in nuclear extracts of 3T3-L1 adipocytes ... In conclusion, our data suggest that insulin and TNF alpha regulate the expression of Foxc2 via a PI3K- and ERK 1/2 dependent pathway in 3T3-L1 adipocytes
Davis et al., J Biol Chem 2004 : In this study, we show that expression of FoxC2 blocks the capacity of 3T3-L1 preadipocytes to undergo adipogenesis in the presence of dexamethasone, isobutylmethylxanthine, and insulin
Fujita et al., Circ Res 2006 (Insulin Resistance) : Here, we demonstrate that Foxc2 is a common transcriptional activator of insulin and TGF-beta signaling to directly regulate PAI-1 expression via 2 distinct target sites, an insulin response element (IRE) and a novel forkhead binding element ( FBE ), adjacent to a Smad binding site
Lidell et al., Diabetes 2011 : We previously showed that a high-calorie diet and insulin induce Foxc2 in adipocytes ; the current findings identify a previously unknown role for Foxc2 as an important metabo-regulator of mitochondrial morphology and metabolism