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IRAK2 — MAP3K7

Pathways - manually collected, often from reviews:

• Reactome Reaction: IRAK2 → MAP3K7 (indirect_complex) Kishimoto et al., J Biol Chem 2000, Sakurai et al., FEBS Lett 2000, Takaesu et al., Mol Cell 2000, Ono et al., J Biol Chem 2001, Kanayama et al., Mol Cell 2004, Sato et al., Nat Immunol 2005, Shim et al., Genes Dev 2005, Brown et al., J Mol Biol 2005, Xia et al., Nature 2009, Kulathu et al., Nature structural & molecular biology 2009*, Shibuya et al., Science 1996
• Reactome Reaction: IRAK2 → MAP3K7 (reaction) Kishimoto et al., J Biol Chem 2000, Sakurai et al., FEBS Lett 2000, Takaesu et al., Mol Cell 2000, Ono et al., J Biol Chem 2001, Kanayama et al., Mol Cell 2004, Sato et al., Nat Immunol 2005, Shim et al., Genes Dev 2005, Brown et al., J Mol Biol 2005, Xia et al., Nature 2009, Kulathu et al., Nature structural & molecular biology 2009*, Shibuya et al., Science 1996

Text-mined interactions from Literome

Takaesu et al., Mol Cell Biol 2001 (MAP Kinase Signaling System) : In this report, we investigate the role of IRAK in the activation of TAK1 ... Genetic analysis reveals that IRAK is required for IL-1 induced activation of TAK1
Qian et al., J Biol Chem 2001 : Our results show that IRAK is required for the IL-1 induced phosphorylation of TAK1 , TAB1, and TAB2
Xiao et al., J Biol Chem 2008 : Importantly, the negative impact of Pellino 3b on IL-1 induced IRAK degradation correlated with the inhibitory effect of Pellino 3b on the IL-1 induced TAK1 dependent pathway, suggesting that a positive role of IRAK degradation in IL-1 induced TAK1 activation
Zhou et al., EMBO J 2013 : IRAK-1 and IRAK-2 , known to form Myddosomes with MyD88-IRAK-4, mediate TLR7 induced TAK1 dependent NF?B activation