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CDK9 — SMAD3

Pathways - manually collected, often from reviews:

• Reactome Reaction: SMAD3 → CDK9 (reaction) Alarcón et al., Cell 2009

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CDK9 — SMAD3 (direct interaction, enzymatic study) Alarcón et al., Cell 2009
• IRef Intact Interaction: Complex of CCNT1-SMAD3-CDK9 (phosphorylation reaction, protein kinase assay) Alarcón et al., Cell 2009

Text-mined interactions from Literome

Mascareno et al., J Biol Chem 2012 (Cardiomegaly...) : It was recently reported that the serine kinase activity of Cdk9 not only targets RNA polymerase II but also the conserved serine residues of the polylinker region in Smad3, suggesting that CLP-1 mediated changes in pTEFb activity may trigger Cdk9 dependent Smad3 signaling that can modulate collagen expression and fibrosis
Cheng et al., Chem Biol 2012 (MAP Kinase Signaling System) : We found that indirubin derivative E738 inhibited both TGFß and BMP pathways through ubiquitin-proteasome mediated depletion of total R-Smad pools, although phospho-R-Smad levels were initially stabilized by GSK3ß and cyclin dependent kinase inhibition