Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
CBL
→
IL6
(increases, IL6 Activity)
Tanaka et al., Mol Cell Biol 2008* Evidence: Here we found that IL-6 stimulation induced lysosome-dependent degradation of gp130, which correlated with an increase in the K63-linked polyubiquitination of gp130. The stimulation-dependent ubiquitination of gp130 was mediated by c-Cbl, an E3 ligase, which was recruited to gp130 in a tyrosine-phosphorylated SHP2-dependent manner.