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NOS2 — S100A12

Text-mined interactions from Literome

Akiba et al., Am J Physiol Gastrointest Liver Physiol 2001 : Antagonism of vanilloid and CGRP receptors, inhibition of nitric oxide synthase , and sensory deafferentation delayed gel thickening, suggesting that the capsaicin pathway mediated the initial burst of mucus secretion that thickened the gel
Liu et al., Shock 2001 : CGRP increased the expression of inducible NOS protein in LPS stimulated macrophages shown by immunocytochemistry method ... The activity of iNOS was also enhanced by CGRP as compared with LPS-stimulation alone by detecting the 3H-L-citruline formation from 3H-L-arginine ... We found that CGRP also increased the LPS induced iNOS mRNA levels by using reverse transcriptase-PCR method ... These data suggest that CGRP enhances LPS induced NO release, iNOS activity, and iNOS mRNA in mouse peritoneal macrophages
Du et al., Int J Cardiol 2004 (Myocardial Infarction) : In the present study, we examined whether CGRP mediated delayed preconditioning induced by nitroglycerin is involved in activation of inducible nitric oxide synthase (iNOS)
Wang et al., Am J Physiol Heart Circ Physiol 2004 (Hyperplasia) : Furthermore, CGRP gene transfer increased inducible nitric oxide synthase and p53 but decreased PCNA and Bcl-2 protein levels in balloon injured rat aorta
Harada et al., Thromb Haemost 2005 (Disease Models, Animal...) : In this process, CGRP induced activation of both endothelial nitric oxide synthase and cyclooxygenase-1 might be critically involved
Bellamy et al., Eur J Neurosci 2006 : Similarly, CGRP promoter activity was also stimulated by nitric oxide donors and overexpression of inducible nitric oxide synthase (iNOS)
E et al., J Invest Dermatol 2006 : CGRP stimulated a modest increase in inducible nitric oxide synthase (iNOS) at 3-6 hours
Li et al., Brain Res 2008 : To our knowledge, this is the first evidence that activation of CGRP1 receptors regulates glial iNOS and NO release
Ariza et al., Magnes Res 2009 (Pre-Eclampsia) : Placental gene expression of CRLR, RAMP1 and iNOS is higher in preeclampsia than in normal pregnancy, and MgSO4 treatment increased CGRP and CRLR and presented opposite effects upon eNOS and iNOS
Vause et al., J Neurochem 2009 (MAP Kinase Signaling System) : The goal of this study was to determine the role of mitogen activated protein kinase ( MAPK ) signaling pathways in CGRP regulation of iNOS expression and NO release from cultured trigeminal ganglion glial cells from Sprague-Dawley rats ... Similarly, pre-treatment with selective MAPK inhibitors repressed increases in reporter gene activity as well as CGRP induced increases in iNOS expression and NO release mediated by MAPKs ... Results from our study provide evidence that CGRP binding to its receptor can stimulate iNOS gene expression via activation of MAPK pathways in trigeminal ganglion glial cells
Yoshimoto et al., Br J Pharmacol 1998 : 8. These results suggest that in the rat aorta, adrenomedullin and alpha-CGRP increase the endothelial [ Ca2+ ] i, activate nitric oxide synthase and release nitric oxide, without a direct inhibitory action on smooth muscle
Taylor et al., Invest Ophthalmol Vis Sci 1998 : Neither CGRP nor aqueous humor suppressed NOS2 protein synthesis in activated inflammatory macrophages