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NOS2 — SMPD2

Text-mined interactions from Literome

Barsacchi et al., Mol Pharmacol 2003 : Activation of endothelial nitric-oxide synthase by tumor necrosis factor-alpha : a novel pathway involving sequential activation of neutral sphingomyelinase , phosphatidylinositol-3 ' kinase, and Akt
Won et al., J Neurochem 2004 : The inhibitor of neutral sphingomyelinase ( 3-O-methylsphingomyelin, MSM ) inhibited the induction of iNOS , whereas inhibitor of acidic sphingomyelinase ( SR33557 ) or that of ceramide de novo synthesis ( fumonisin B1 ) had no effect on the induction of iNOS ... Inhibition of co-transfected iNOS promoter activity by dominant negative ras supported the role of ras in the nSMase dependent regulation of iNOS gene
Zeng et al., J Neurochem 2005 (Infection) : Moreover, the specific nSMase inhibitor, 3-O-methyl-sphingomyelin ( 3-OMS ), inhibited iNOS expression and nitrite production induced by TNF-alpha or by the combination of TNF-alpha and Abeta