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CDKN1A — ESR1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Gartel et al., Proc Natl Acad Sci U S A 2001
:
We found that activation of a
Myc-estrogen receptor fusion protein by 4-hydroxytamoxifen in mouse cells
resulted in suppression of endogenous
p21 transcription
Lazennec et al., Endocrinology 2001
(Breast Neoplasms...) :
ER beta and
ER alpha induced the expression of several endogenous genes such as pS2, TGF alpha, or the cyclin kinase inhibitor
p21 but, in contrast to ER alpha, ER beta was unable to regulate c-myc proto-oncogene expression
Zhao et al., J Cell Biochem 2004
(Breast Neoplasms) :
Elevated expression of the
estrogen receptor prevents the down-regulation of
p21Waf1/Cip1 in hormone dependent breast cancer cells
Maynadier et al., FASEB J 2008
(Breast Neoplasms) :
We further demonstrate that the unliganded full-length
ER alpha or the variant having the p21 ( WAF1 ) interaction region significantly
increases p21 ( WAF1 ) expression, whereas ER alpha silencing reduces p21 ( WAF1 ) levels and silencing of p21 ( WAF1 ) is sufficient to prevent ER alpha induced growth inhibition