Gene interactions and pathways from curated databases and text-mining

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ERVK-6 — IL8

Text-mined interactions from Literome

Smith et al., Clin Immunol Immunopathol 1992 : Induction of neutral proteinase and prostanoid production in bovine nasal chondrocytes by interleukin-1 and tumor necrosis factor alpha : modulation of these cellular responses by interleukin-6 and platelet derived growth factor
da Costa Pinheiro et al., Infect Immun 2005 (Leishmaniasis, Visceral) : High in vitro lymphoproliferative responses were induced in humans and dogs by a recombinant Leishmania ( Leishmania ) chagasi cysteine proteinase , with secretion of IFN-gamma in asymptomatic subjects or of IFN-gamma, interleukin 4 (IL-4), and IL-10 in oligosymptomatic subjects
Ma et al., Biochim Biophys Acta 2006 (Inflammation) : Tryptase is involved in proteinase activated receptor-2 (PAR-2) mediated up-regulation of IL-8 expression
Wang et al., Int J Biochem Cell Biol 2006 : It was reported that thrombin could induce IL-8 secretion from human dermal fibroblasts ( HDFs ) through activation of proteinase activated receptor (PAR)-1
Inomata et al., Microbes Infect 2007 : We found that arginine-specific gingipain A ( RgpA ) increased the responsiveness of vascular endothelial cells to P. gingivalis lipopolysaccharides (LPS) and P. gingivalis whole cells to induce enhanced IL-8 production through protease activated receptors (PARs) and phospholipase C (PLC) gamma
Ostrowska et al., Biochem Biophys Res Commun 2008 : Protease activated receptor (PAR) induced interleukin-8 production in airway epithelial cells requires activation of MAP kinases p44/42 and JNK
Yoshida et al., J Pharmacol Sci 2008 (Gastroenteritis...) : It has been also proposed that Helicobacter pylori ( H. pylori ) induces PAR expression in the gastric epithelial cells and H. pylori derived serine proteinase promotes IL-8 production via PAR in the epithelial cells
Acharjee et al., Brain 2011 (Acquired Immunodeficiency Syndrome...) : In vivo feline immunodeficiency virus infection was associated with increased proteinase activated receptor-1 expression on neurons and interleukin-1ß induction in macrophages
Berger et al., J Am Soc Nephrol 1996 (Autoimmune Diseases...) : Proteinase 3, the major autoantigen of Wegener 's granulomatosis, enhances IL-8 production by endothelial cells in vitro