Gene interactions and pathways from curated databases and text-mining

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EGFR — MUC1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Shim et al., Am J Physiol Lung Cell Mol Physiol 2001 (Metaplasia) : These findings indicate that EGFR signaling is involved in IL-13 induced mucin production
Takeyama et al., Am J Respir Crit Care Med 2001 (Asthma) : These findings suggest a sequence of events by which EGFR activation is involved in mucin expression in asthmatic airway epithelium
Li et al., J Biol Chem 2001 : The results demonstrate that EGF-R mediated phosphorylation of MUC1 induces binding of MUC1 to c-Src in cells ... Moreover, in vitro and in vivo studies demonstrate that EGF-R increases binding of MUC1 and beta-catenin ... These findings support a novel role for EGF-R in regulating interactions of MUC1 with c-Src and beta-catenin
Nadel et al., Respir Res 2001 (Asthma...) : Role of epidermal growth factor receptor activation in regulating mucin synthesis
Gray et al., Mol Pharmacol 2004 : However, neither inhibition of epidermal growth factor receptor (EGFR) activation with the tyrosine kinase inhibitor 4- ( 3-chloroanilino ) -6,7-dimethoxyquinazoline HCl ( AG-1478 ) or EGFR blocking antibody nor inhibition of extracellular signal regulated kinase/P-38 mitogen activated protein kinases with specific inhibitors blocked IL-1beta stimulation of MUC5AC mucin production
Mao et al., Zhonghua Jie He He Hu Xi Za Zhi 2004 (Pulmonary Disease, Chronic Obstructive) : It is suggested that EGFR activation is involved in mucin expression in COPD airways
Burgel et al., Thorax 2004 : Roles of epidermal growth factor receptor activation in epithelial cell repair and mucin production in airway epithelium
Slomiany et al., Inflammopharmacology 2004 : Using [ ( 3 ) H ] glucosamine labeled mucous acinar cells of sublingual salivary gland in culture, we show that stimulatory effect of beta-adrenergic agonist, isoproterenol, on mucin secretion was inhibited in a concentration dependent manner by EGFR kinase inhibitor, PD153035, as well as wortmannin, an inhibitor of PI3K
Deshmukh et al., Am J Respir Crit Care Med 2005 : Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation
Piludu et al., Eur J Morphol 2003 : Since this pattern of labelling must be related to the internalisation process of the ligand-GFR complex, our results support the hypothesis that EGFR activation takes place in mucous cells and affects mucin production in human salivary glands
Słomiany et al., J Physiol Pharmacol 2005 : Using [ ( 3 ) H ] glucosamine labeled gastric mucosal cells, we show that stimulatory effect of beta-adrenergic agonist, isoproterenol, on mucin secretion was inhibited by EGFR kinase inhibitor, PD153035, as well as wortmannin, a specific inhibitor of PI3K
Kim et al., Am J Physiol Lung Cell Mol Physiol 2005 : In previous work, we showed that epidermal growth factor receptor (EGFR) activation causes mucin expression in airway epithelium in vivo and in human NCI-H292 airway epithelial cells and normal human bronchial epithelial ( NHBE ) cells in vitro ... In support of this hypothesis, in dense cultures of NCI-H292 cells and in NHBE cells at air-liquid interface, blockade of E-cadherin mediated cell-cell contacts decreased EGFR dependent mucin production ... E-cadherin blockade also increased EGFR dependent cell proliferation and TGF-alpha induced EGFR tyrosine phosphorylation in dense cultures of NCI-H292 cells, suggesting that E-cadherin promotes EGFR dependent mucin production and inhibits EGFR dependent cell proliferation via modulation of EGFR phosphotyrosine levels
Li et al., Cancer Biol Ther 2005 (Carcinoma...) : These results demonstrate a role for MUC1 in the regulation of EGFR expression and suggest that MUC1 gene silencing may represent a novel therapeutic approach in the treatment of a variety of human cancers
Baginski et al., Am J Respir Cell Mol Biol 2006 (Carcinoma, Mucoepidermoid) : CSE also enhanced expression and production of MUC5AC mucin induced by epidermal growth factor receptor (EGFR) ligands TGF-alpha and amphiregulin, as well as LPS- and TNF-alpha- induced expression and/or release of TGF-alpha and amphiregulin ... Furthermore, ( 4- [ ( 3-bromophenyl ) amino ] -6,7-diaminoquinazoline ), a potent inhibitor of EGFR , blocked synergistic induction of MUC5AC mucin
Zhen et al., Am J Respir Cell Mol Biol 2007 (Metaplasia) : However, there was constitutive release of TGF-alpha from normal human bronchial epithelial cells, and inhibition of TGF-alpha or EGFR reduced both constitutive and IL-13 induced mucin production
Griffin et al., Cell Microbiol 2007 : We now show that a large of number of stimuli relevant to the cystic fibrosis lung - neutrophil elastase, LPS, Pam3Cys-Ser- ( Lys ) 4 Hydrochloride ( a lipopeptide analogue ), CpG DNA ( which mimics bacterial DNA ) and cystic fibrosis bronchoalveolar lavage fluid - can activate MUC1 and 2 expression as well as MUC5AC expression in lung epithelial cells via an EGFR dependent mechanism
Hegab et al., Chest 2007 (Bronchial Neoplasms...) : Both in vivo and in vitro, the induction of MUC5AC and mucin synthesis were inhibited by niflumic acid, and/or a selective EGFR tyrosine kinase inhibitor, AG-1478
Pochampalli et al., Cancer Res 2007 (Disease Models, Animal...) : Previous studies in our laboratory showed that EGFR could also be affected by the glycoprotein MUC1 , which inhibits ligand stimulated degradation of EGFR in breast epithelial cell lines
Bitler et al., J Cell Sci 2010 (Breast Neoplasms...) : Importantly, we found that the loss of MUC1 expression resulted in a decrease in the interaction between EGFR and the CCND1 promoter, which translated to a significant decrease in cyclin D1 protein expression
Qi et al., Eur Cytokine Netw 2010 : It is known that activation of epidermal growth factor receptor (EGFR) and its downstream signaling cascade are involved in mucin production ... In this investigation, we demonstrate that NE-induced mucin production requires reactive oxygen species ( ROS ) production, which activates TACE, resulting in TGF-a shedding, and EGFR phosphorylation in NCI-H292 epithelial cells
Rada et al., Mucosal Immunol 2011 (Cystic Fibrosis) : Reactive oxygen species mediate inflammatory cytokine release and EGFR dependent mucin secretion in airway epithelial cells exposed to Pseudomonas pyocyanin
Karacsonyi et al., Am J Respir Cell Mol Biol 2012 : Epidermal growth factor receptor signaling mediates vesicant induced airway epithelial secretion of interleukin-6 and production of mucin ... This study assessed the role of epidermal growth factor receptor (EGFR) signaling in mediating the effects of exposure to vesicants on the secretion of cytokines and production of mucin in human airway epithelial cells
Kosugi et al., PloS one 2011 (Neoplasms) : In addition, EGFR mediated phosphorylation of MUC1-C in breast cancer cells was associated with decreases in PKM2 activity
Kim et al., PloS one 2012 : Here, we show that Pumilio ( Pum ) , an RNA binding translational repressor, negatively regulates EGFR signaling in wing vein and bristle development
Neeraja Dharmaraj et al., J Cell Biochem 2013 : Activated EGFR stimulates MUC1 expression in human uterine and pancreatic cancer cell lines ... Collectively, these data demonstrate that : ( 1 ) activation of EGFR stimulates MUC1 expression in multiple cellular contexts and ( 2 ) it may be possible to develop useful interventions to reduce MUC1 expression as a complementary strategy for tumor therapy
Guddo et al., J Clin Pathol 1998 (Carcinoma, Non-Small-Cell Lung...) : MUC1 ( episialin ) expression in non-small cell lung cancer is independent of EGFR and c-erbB-2 expression and correlates with poor survival in node positive patients