◀ Back to EGFR
EGFR — MUC1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
EGFR
—
MUC1
(colocalization, imaging technique)
Merlin et al., Oncogene 2011*
-
IRef Biogrid Interaction:
EGFR
—
MUC1
(physical association, affinity chromatography technology)
Merlin et al., Oncogene 2011*
-
IRef Biogrid Interaction:
EGFR
—
MUC1
(physical association, affinity chromatography technology)
Schroeder et al., J Biol Chem 2001*
-
IRef Biogrid Interaction:
EGFR
—
MUC1
(physical association, affinity chromatography technology)
Li et al., J Biol Chem 2001*
-
IRef Biogrid Interaction:
EGFR
—
MUC1
(direct interaction, enzymatic study)
Li et al., J Biol Chem 2001*
-
IRef Biogrid Interaction:
EGFR
—
MUC1
(physical association, affinity chromatography technology)
Pochampalli et al., Oncogene 2007*
-
IRef Hprd Interaction:
EGFR
—
MUC1
(in vitro)
Schroeder et al., J Biol Chem 2001*, Li et al., J Biol Chem 2001*
-
IRef Hprd Interaction:
EGFR
—
MUC1
(in vivo)
Schroeder et al., J Biol Chem 2001*, Li et al., J Biol Chem 2001*
-
IRef Innatedb Interaction:
MUC1
—
EGFR
(unknown, -)
Ramasamy et al., Mol Cell 2007*
-
IRef Intact Interaction:
MUC1
—
EGFR
(physical association, cross-linking study)
Li et al., J Biol Chem 2001*
-
IRef Intact Interaction:
MUC1
—
EGFR
(physical association, coimmunoprecipitation)
Li et al., J Biol Chem 2001*
-
IRef Intact Interaction:
MUC1
—
EGFR
(physical association, anti bait coimmunoprecipitation)
Merlin et al., Oncogene 2011*
-
IRef Ophid Interaction:
MUC1
—
EGFR
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Shim et al., Am J Physiol Lung Cell Mol Physiol 2001
(Metaplasia) :
These findings indicate that
EGFR signaling is
involved in IL-13 induced
mucin production
Takeyama et al., Am J Respir Crit Care Med 2001
(Asthma) :
These findings suggest a sequence of events by which
EGFR activation is
involved in
mucin expression in asthmatic airway epithelium
Li et al., J Biol Chem 2001
:
The results demonstrate that
EGF-R mediated phosphorylation of
MUC1 induces binding of MUC1 to c-Src in cells ... Moreover, in vitro and in vivo studies demonstrate that
EGF-R increases binding of
MUC1 and beta-catenin ... These findings support a novel
role for
EGF-R in regulating interactions of
MUC1 with c-Src and beta-catenin
Nadel et al., Respir Res 2001
(Asthma...) :
Role of
epidermal growth factor receptor activation in regulating
mucin synthesis
Gray et al., Mol Pharmacol 2004
:
However, neither inhibition of
epidermal growth factor receptor (EGFR) activation with the tyrosine kinase inhibitor 4- ( 3-chloroanilino ) -6,7-dimethoxyquinazoline HCl ( AG-1478 ) or EGFR blocking antibody nor inhibition of extracellular signal regulated kinase/P-38 mitogen activated protein kinases with specific inhibitors
blocked IL-1beta stimulation of MUC5AC
mucin production
Mao et al., Zhonghua Jie He He Hu Xi Za Zhi 2004
(Pulmonary Disease, Chronic Obstructive) :
It is suggested that
EGFR activation is
involved in
mucin expression in COPD airways
Burgel et al., Thorax 2004
:
Roles of
epidermal growth factor receptor activation in epithelial cell repair and
mucin production in airway epithelium
Slomiany et al., Inflammopharmacology 2004
:
Using [ ( 3 ) H ] glucosamine labeled mucous acinar cells of sublingual salivary gland in culture, we show that stimulatory effect of beta-adrenergic agonist, isoproterenol, on
mucin secretion was
inhibited in a concentration dependent manner by
EGFR kinase inhibitor, PD153035, as well as wortmannin, an inhibitor of PI3K
Deshmukh et al., Am J Respir Crit Care Med 2005
:
Metalloproteinases
mediate mucin 5AC expression by
epidermal growth factor receptor activation
Piludu et al., Eur J Morphol 2003
:
Since this pattern of labelling must be related to the internalisation process of the ligand-GFR complex, our results support the hypothesis that
EGFR activation takes place in mucous cells and
affects mucin production in human salivary glands
Słomiany et al., J Physiol Pharmacol 2005
:
Using [ ( 3 ) H ] glucosamine labeled gastric mucosal cells, we show that stimulatory effect of beta-adrenergic agonist, isoproterenol, on
mucin secretion was
inhibited by
EGFR kinase inhibitor, PD153035, as well as wortmannin, a specific inhibitor of PI3K
Kim et al., Am J Physiol Lung Cell Mol Physiol 2005
:
In previous work, we showed that
epidermal growth factor receptor (EGFR) activation
causes mucin expression in airway epithelium in vivo and in human NCI-H292 airway epithelial cells and normal human bronchial epithelial ( NHBE ) cells in vitro ... In support of this hypothesis, in dense cultures of NCI-H292 cells and in NHBE cells at air-liquid interface, blockade of E-cadherin mediated cell-cell contacts decreased
EGFR dependent
mucin production ... E-cadherin blockade also increased EGFR dependent cell proliferation and TGF-alpha induced EGFR tyrosine phosphorylation in dense cultures of NCI-H292 cells, suggesting that E-cadherin promotes
EGFR dependent
mucin production and inhibits EGFR dependent cell proliferation via modulation of EGFR phosphotyrosine levels
Li et al., Cancer Biol Ther 2005
(Carcinoma...) :
These results demonstrate a
role for
MUC1 in the regulation of
EGFR expression and suggest that MUC1 gene silencing may represent a novel therapeutic approach in the treatment of a variety of human cancers
Baginski et al., Am J Respir Cell Mol Biol 2006
(Carcinoma, Mucoepidermoid) :
CSE also enhanced expression and production of MUC5AC
mucin induced by
epidermal growth factor receptor (EGFR) ligands TGF-alpha and amphiregulin, as well as LPS- and TNF-alpha- induced expression and/or release of TGF-alpha and amphiregulin ... Furthermore, ( 4- [ ( 3-bromophenyl ) amino ] -6,7-diaminoquinazoline ), a potent inhibitor of
EGFR ,
blocked synergistic induction of MUC5AC
mucin
Zhen et al., Am J Respir Cell Mol Biol 2007
(Metaplasia) :
However, there was constitutive release of TGF-alpha from normal human bronchial epithelial cells, and inhibition of TGF-alpha or
EGFR reduced both constitutive and IL-13 induced
mucin production
Griffin et al., Cell Microbiol 2007
:
We now show that a large of number of stimuli relevant to the cystic fibrosis lung - neutrophil elastase, LPS, Pam3Cys-Ser- ( Lys ) 4 Hydrochloride ( a lipopeptide analogue ), CpG DNA ( which mimics bacterial DNA ) and cystic fibrosis bronchoalveolar lavage fluid - can activate
MUC1 and 2 expression as well as MUC5AC expression in lung epithelial cells via an
EGFR dependent mechanism
Hegab et al., Chest 2007
(Bronchial Neoplasms...) :
Both in vivo and in vitro, the induction of MUC5AC and
mucin synthesis were
inhibited by niflumic acid, and/or a selective
EGFR tyrosine kinase inhibitor, AG-1478
Pochampalli et al., Cancer Res 2007
(Disease Models, Animal...) :
Previous studies in our laboratory showed that
EGFR could also be
affected by the glycoprotein
MUC1 , which inhibits ligand stimulated degradation of EGFR in breast epithelial cell lines
Bitler et al., J Cell Sci 2010
(Breast Neoplasms...) :
Importantly, we found that the loss of
MUC1 expression
resulted in a decrease in the interaction between
EGFR and the CCND1 promoter, which translated to a significant decrease in cyclin D1 protein expression
Qi et al., Eur Cytokine Netw 2010
:
It is known that activation of
epidermal growth factor receptor (EGFR) and its downstream signaling cascade are
involved in
mucin production ... In this investigation, we demonstrate that NE-induced
mucin production
requires reactive oxygen species ( ROS ) production, which activates TACE, resulting in TGF-a shedding, and
EGFR phosphorylation in NCI-H292 epithelial cells
Rada et al., Mucosal Immunol 2011
(Cystic Fibrosis) :
Reactive oxygen species mediate inflammatory cytokine release and
EGFR dependent
mucin secretion in airway epithelial cells exposed to Pseudomonas pyocyanin
Karacsonyi et al., Am J Respir Cell Mol Biol 2012
:
Epidermal growth factor receptor signaling
mediates vesicant induced airway epithelial secretion of interleukin-6 and production of
mucin ... This study assessed the
role of
epidermal growth factor receptor (EGFR) signaling in mediating the effects of exposure to vesicants on the secretion of cytokines and production of
mucin in human airway epithelial cells
Kosugi et al., PloS one 2011
(Neoplasms) :
In addition,
EGFR mediated phosphorylation of
MUC1-C in breast cancer cells was associated with decreases in PKM2 activity
Kim et al., PloS one 2012
:
Here, we show that
Pumilio ( Pum ) , an RNA binding translational repressor, negatively
regulates EGFR signaling in wing vein and bristle development
Neeraja Dharmaraj et al., J Cell Biochem 2013
:
Activated
EGFR stimulates
MUC1 expression in human uterine and pancreatic cancer cell lines ... Collectively, these data demonstrate that : ( 1 ) activation of
EGFR stimulates
MUC1 expression in multiple cellular contexts and ( 2 ) it may be possible to develop useful interventions to reduce MUC1 expression as a complementary strategy for tumor therapy
Guddo et al., J Clin Pathol 1998
(Carcinoma, Non-Small-Cell Lung...) :
MUC1 ( episialin ) expression in non-small cell lung cancer is
independent of
EGFR and c-erbB-2 expression and correlates with poor survival in node positive patients