Su et al., J Exp Ther Oncol 2007
(Breast Neoplasms) :
Reporter assays in MCF-7 cells indicated that Dip1 strongly inhibited the transcriptional activities of the cyclin D1, c-fos, NF-kappaB, SRE and p21cP1 promoters
Inoue et al., Genes Dev 2013
(Cell Transformation, Neoplastic...) :
Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1 mediated down-regulation of p21 and p15 ... Notably, in the absence of Mule, c-Myc/Miz1 transcriptional complexes accumulated, and levels of p21CDKN1A ( p21 ) and p15INK4B ( p15 ) were down-regulated