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Mahdi et al., Cell Prolif 2010
(Fibrosarcoma) :
In addition, 2HBZ caused a marked increase in p21, p53 and Bax protein expressions and these effects were associated with an increase in G1 and G2 arrest of the cell cycle and a reduction in S-phase
Hagiya et al., Retrovirology 2011
(Leukemia-Lymphoma, Adult T-Cell) :
ATF3 also enhanced p53 transcriptional activity, but this activity was suppressed by HBZ