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HSP90AA1 — MYC

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MYC — HSP90AA1 (physical association, affinity chromatography technology) Carystinos et al., Mol Pharmacol 2003*
• IRef Hprd Interaction: MYC — HSP90AA1 (in vivo) Carystinos et al., Mol Pharmacol 2003*
• IRef Ophid Interaction: MYC — HSP90AA1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Teng et al., J Biol Chem 2004 (Cell Transformation, Neoplastic) : Direct activation of HSP90A transcription by c-Myc contributes to c-Myc induced transformation ... Here we show that c-Myc directly activates HSP90A transcription ... c-Myc mediated induction of HSP90A transcription occurs in different tissues, is independent of cell proliferation, and is mediated by a c-Myc binding site in the proximal promoter region of HSP90A gene
Li et al., Virology journal 2010 : The regulation of c-Myc mediated HSP90 alpha promoter transactivation by HBx was evaluated through electrophoretic mobility shift analysis ( EMSA ) ... In addition, the luciferase activity of the HSP90alpha promoter analysis revealed that the HBx is directly involved in the c-Myc mediated transcriptional activation of HSP90alpha
Bansal et al., Blood 2010 (Leukemia, Myeloid) : Furthermore, Hsp90 inhibitors 17-AAG [ 17- ( allylamino ) -17-demethoxygeldanamycin ] and STA-9090 significantly reduced the growth of myeloid leukemia xenografts in vivo and effectively down-regulated the expression of WT1 and its downstream target proteins, c-Myc and Bcl-2
Regan et al., Int J Oncol 2011 (Neuroblastoma) : It was found that Hsp90 inhibition in neuroblastoma cell lines resulted in significant growth suppression, a decrease in MYCN and MYC expression, and an increase in the expression of p53