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CLU — TGFB1
Text-mined interactions from Literome
Wegrowski et al., Exp Cell Res 1999
:
The activator protein-1 binding site partly directed the
TGFbeta1 stimulated
clusterin expression
Zenkel et al., Invest Ophthalmol Vis Sci 2006
(Exfoliation Syndrome...) :
Real-time PCR and Western blot analysis were used to study the
effect of
TGF-beta1 , which is significantly increased in the aqueous humor of PEX eyes, on
clusterin expression by nonpigmented ciliary epithelial cells in vitro
Itahana et al., Exp Cell Res 2007
:
On the other hand, the second and most dramatic up-regulation of
clusterin can be
due to the potent induction by
TGF-beta1 , and this up-regulation by TGF-beta1 is dependent on beta1 integrin ligand binding activity
Jurkunas et al., Invest Ophthalmol Vis Sci 2009
(Fuchs' Endothelial Dystrophy) :
Colocalization of increased
transforming growth factor-beta induced protein ( TGFBIp ) and
Clusterin in Fuchs endothelial corneal dystrophy
Morgan et al., J Neuroimmunol 1995
:
This study characterizes the
effect of
transforming growth factor (TGF) beta 1 on
clusterin expression in rat brain cells ... However, in cultures of astrocytes that contained microglia and oligodendrocytes ( mixed glia cultures ),
TGF-beta 1 caused a dose dependent increase in astrocytic
clusterin mRNA levels ...
TGF-beta 1 increased
clusterin protein in the conditioned medium from cultured glia, in either monotypic or mixed glial cultures
Laping et al., J Am Soc Nephrol 1997
:
Epidermal growth factor, insulin-like growth factor-1, and
transforming growth factor-beta 1 had little or no effect on
clusterin mRNA levels