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CXCR4 — TGFB1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CXCR4 → TGFB1 (increases) Buckley et al., J Immunol 2000*
  Evidence: TGF-Beta1 at a concentration of 2 ng/ml induced a 10-fold increase in the level of CXCR4 expressed on synovial CD4 T cells after 48 hours of incubation.
• OpenBEL Selventa BEL large corpus: CXCR4 → TGFB1 (decreases, TGFB1 Translocation) Wang et al., J Biol Chem 2001*
  Evidence: and up-regulated by IL-10 and transforming growth factor-beta 1. Down-regulation was mediated post-translationally, in the absence of protein degradation, through an endocytotic mechanism.

Text-mined interactions from Literome

Sato et al., J Immunol 2000 : Stimulation of mature DCs with TGF-beta 1 also enhanced TNF-alpha induced down-regulation of the expressions of CCR-1, CCR-3, CCR-5, CCR-6, and CXCR-4 , and chemotaxis to their respective ligands, while this stimulation suppressed TNF-alpha induced expression of CCR-7 and chemotactic migratory ability to MIP-3 beta
Buckley et al., J Immunol 2000 (Arthritis, Rheumatoid) : Persistent induction of the chemokine receptor CXCR4 by TGF-beta 1 on synovial T cells contributes to their accumulation within the rheumatoid synovium ... Depletion studies using synovial fluid confirmed an important role for TGF-beta1 in the induction of CXCR4 expression in vivo ... These results suggest that the persistent induction of CXCR4 on synovial T cells by TGF-beta1 leads to their active, SDF-1 mediated retention in a perivascular distribution within the rheumatoid synovium
Bartolomé et al., Cancer Res 2004 (Lymphatic Metastasis...) : Furthermore, CXCR4 expression on melanoma cells was notably augmented by transforming growth factor-beta1 , a Matrigel component, whereas anti transforming growth factor-beta antibodies inhibited increases in CXCR4 expression and melanoma cell invasion toward SDF-1alpha ... Furthermore, CXCR4 expression on melanoma cells was notably augmented by transforming growth factor-beta1 , a Matrigel component, whereas anti transforming growth factor-beta antibodies inhibited increases in CXCR4 expression and melanoma cell invasion toward SDF-1alpha
Chen et al., Immunology 2005 (HIV Infections) : Transforming growth factor-beta1 increases CXCR4 expression, stromal derived factor-1alpha stimulated signalling and human immunodeficiency virus-1 entry in human monocyte derived macrophages ... The purpose of this study was to evaluate the effects of TGF-beta1 on CXCR4 expression and function in primary human monocyte derived macrophages ( MDMs ) and rat microglia ... TGF-beta1 up-regulated CXCR4 and enhanced SDF-1alpha stimulated ERK1,2 phosphorylation in these cells
Taki et al., Oncol Rep 2008 (Carcinoma, Squamous Cell...) : Furthermore, SDF-1alpha and TGF-beta1 up-regulated the expression of CXCR4 and cell migratory activity in these cells
Kim et al., Leukemia & lymphoma 2009 (Anoxia...) : Tumor necrosis factor-alpha (TNF-alpha), transforming growth factor-beta1 ( TGF-beta1 ), and vascular endothelial growth factor ( VEGF ) enhanced CXCR4 expression in RPMI8226 cells
Hirakawa et al., Am J Pathol 2009 (Lymphatic Metastasis...) : A431 cells overexpressing Snail expressed increased levels of CXCR4 in the presence of transforming growth factor-beta1
Zhao et al., Acta Pharmacol Sin 2010 (Breast Neoplasms) : Transforming growth factor-beta1 upregulates the expression of CXC chemokine receptor 4 (CXCR4) in human breast cancer MCF-7 cells
Zoeteweij et al., J Immunol 1998 (HIV Infections) : Expression of cell surface CXCR4 on cLC was up-regulated by IL-4 and TGF-beta1 and inhibited by IFN-alpha, IFN-beta, and IFN-gamma, whereas cytokines did not appreciably regulate CCR5