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CD4 — IL17D

Text-mined interactions from Literome

Takeda et al., J Immunol 2003 : Although IL-27 did not directly induce IFN-gamma production by wild-type CD4 ( + ) T cells, IL-12 dependent IFN-gamma production was augmented by IL-27 stimulation in wild-type naive CD4 ( + ) T cells but was impaired in WSX-1-deficient naive CD4 ( + ) T cells
Villarino et al., Int Immunol 2008 (Chronic Disease...) : In both models of intestinal inflammation, improved clinical outcome was associated with reduced inflammation and profound attenuation of T ( h ) 1 responses and, consistent with these in vivo findings, we confirmed that during in vitro differentiation, IL-27 directly promotes CD4 ( + ) T cell IFN-gamma production through effects on Tbet, a key T ( h ) 1 transcription factor
Charlot-Rabiega et al., J Biol Chem 2011 : IL-27 proliferative effect on naive CD4 ( + ) T cells is independent of MAPK, but is dependent on c-Myc and Pim-1 induction by IL-27 and is associated with induction of cyclin D2, cyclin D3, and CDK4 by IL-27 in a c-Myc and Pim-1 dependent manner
Wojno et al., Trends Immunol 2012 : This review discusses recent work that has explored the effect of IL-27 on CD4 ( + ) T cell subsets, including T regulatory type 1 (Tr-1) cells, T follicular helper cells ( Tfhs ), and forkhead box P3 (Foxp3) ( + ) T regulatory cells ( Tregs )
Iwasaki et al., Eur J Immunol 2013 : Egr-2 transcription factor is required for Blimp-1 mediated IL-10 production in IL-27 stimulated CD4 ( + ) T cells
Gwyer Findlay et al., J Immunol 2013 (Inflammation...) : Surprisingly, however, the role of IL-27 in restricting or shaping effector CD4 ( + ) T cell chemotactic responses, as a mechanism to reduce T cell dependent tissue inflammation, is unknown ... These data reveal a previously unappreciated role for IL-27 in modulating CD4 ( + ) T cell chemotactic pathways during infection, which is related to its capacity to repress Th1 effector cell development