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PTGS2 — VIP
Text-mined interactions from Literome
Fernández-Martínez et al., Mol Cell Endocrinol 2007
(Disease Progression...) :
The
effect of
vasoactive intestinal peptide (VIP) on
cyclooxygenase-2 (COX-2) expression was analyzed in human prostate non-neoplastic ( RWPE-1 ) as well as cancer androgen dependent ( LNCaP ) and independent ( PC3 ) cells ... Furthermore,
VIP induced higher levels of
COX-2 protein expression in cancer cells as compared with non-neoplastic cells ... The anti-inflammatory agent curcumin blocked
VIP induced
COX-2 expression in all cell lines studied supporting the involvement of nuclear factor-kappaB (NFkappaB) in such a response ... These results together with the existence of two NFkappaB sites in the COX-2 gene promoter together suggest that
COX-2 may be a
target for
VIP in prostate cancer progression
Gonzalez-Rey et al., Brain Behav Immun 2008
(Inflammation) :
In this work we show the inhibitory
effect of
VIP on
COX-2 expression and subsequent production of PGE2 by macrophages, dendritic cells, and microglia activated with different inflammatory stimuli
Fernández-Martínez et al., Peptides 2009
(Prostatic Neoplasms) :
The regulatory
role of
VIP on
cyclooxygenase-2 (COX-2) and vascular endothelial growth factor ( VEGF ) expression as well as on matrix metalloproteinase-2 and 9 ( MMP-2 and 9 ) activities was examined