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IL13 — MMP1
Text-mined interactions from Literome
Meisser et al., Mol Hum Reprod 1999
:
The aim of this study was to determine the
effects of tumour necrosis factor alpha (TNF),
interleukin-1 alpha (IL-1alpha), macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of
matrix metalloproteinases ( MMP ) , human chorionic gonadotrophin ( HCG ) and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro
Oriente et al., J Pharmacol Exp Ther 2000
:
Finally,
IL-13 inhibited IL-1beta induced
matrix metalloproteinase (MMP)-1 and MMP-3 production and enhanced tissue inhibitor of metalloproteinase ( TIMP ) -1 generation from NF ; although similar effects were observed with IL-4, TGF-beta(1) transiently enhanced MMP-1 and MMP-3 generation without effecting TIMP-1
Cleaver et al., Ann Rheum Dis 2001
:
Northern blot analyses were performed to determine the
effects of
IL13 on the induction of
matrix metalloproteinase-1 (MMP-1) , MMP-3, MMP-13, and TIMP-1 gene expression ... Northern blot analysis showed that
IL13 down
regulated MMP-3 and MMP-13 levels but up regulated
MMP-1 and TIMP-1 gene expression in bovine nasal chondrocytes at 24 hours
Ray et al., Arthritis Rheum 2003
(Osteoarthritis) :
Overexpression of SAF-1 in OA chondrocytes increased the expression of the MMP1 promoter, and interference of endogenous SAF-1 activity by antisense SAF-1 messenger RNA inhibited
interleukin-1 mediated
MMP1 promoter activity
Sun et al., Connect Tissue Res 2003
(Arthritis, Rheumatoid) :
Furthermore, the
induction of the
MMP expression and activities by
interleukin-1 was suppressed by the oscillatory shear
Ma et al., J Immunol 2004
(Inflammation) :
C10/CCL6 neutralization also decreased the ability of
IL-13 to
stimulate the production of monocyte chemoattractant protein-1, macrophage inflammatory protein-1alpha,
MMP-2 , MMP-9, and cathepsins-K, -L, and -S and the ability of IL-13 to inhibit alpha1-antitrypsin
Madala et al., J Immunol 2010
(Fibrosis...) :
Instead, we observed marked increases in MMP2 and MMP13 expression, suggesting that Mmp12 was promoting fibrosis by limiting the expression of specific ECM degrading MMPs. Interestingly, like MMP12,
MMP13 expression was highly
dependent on
IL-13 and type II-IL-4 receptor signaling
Abe et al., J Nat Prod 2010
:
The effects of these new compounds on
interleukin-1ß induced production of
matrix metalloproteinase-1 (MMP-1) in human dermal fibroblasts were examined
Saw et al., Am J Pathol 2011
(Fibrosis...) :
Differences between pemphigoid and normal conjunctival fibroblasts with respect to collagen contraction and
MMP secretion in the
presence of
interleukin-13 were also observed
Fujisawa et al., Int J Cancer 2012
(Neoplasm Invasiveness...) :
Mechanistically,
IL-13 enhanced ERK1/2, AP-1 and
MMP activities only in IL-13Ra2 positive cells but not in IL-13Ra2 negative cells
Bailey et al., PloS one 2012
(Crohn Disease...) :
Fibroblasts from intestinal muscle expressed Ra1, phosphorylated STAT6 in
response to
IL-13 , and subsequently down-regulated MMP-2 and TNF-a induced
MMP-1 and MMP-9 synthesis
Gotoh et al., Connect Tissue Res 2013
:
Extracellular ß-NAD ( + ) inhibits
interleukin-1 induced
matrix metalloproteinase-1 and -3 expression on human gingival fibroblasts
Langdon et al., Arthritis Rheum 1997
(Arthritis, Rheumatoid) :
Oncostatin M stimulates monocyte chemoattractant protein-1- and
interleukin-1 induced
matrix metalloproteinase-1 production by human synovial fibroblasts in vitro
Dean et al., J Biol Chem 1999
:
We have previously shown that the pyridinyl imidazole SB 203580, which inhibits it, blocks the
interleukin-1 induction of cyclooxygenase-2 (COX-2) and
matrix metalloproteinase 1 and 3 mRNAs in fibroblasts