Gene interactions and pathways from curated databases and text-mining

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CA2 — CASP4

Text-mined interactions from Literome

Xiao et al., J Neurosci 2002 (Necrosis) : Potassium channel blockers or high K+ medium, but not Ca2+ channel blockade, prevented cytochrome c release, caspase activation, and DNA damage
Yoon et al., J Neurochem 2003 : Reducing extracellular Ca2+ , but not Na+, activated caspase-3 , suggesting an essential role of Ca2+ deficiency in MK-801/CNQX induced activation of caspases
Sergeev et al., Biochem Biophys Res Commun 2004 (Breast Neoplasms) : Selective inhibition of Ca2+ binding sites of mu-calpain, forced increase of the cytosolic Ca2+ buffering capacity, and caspase inhibition decreased apoptotic indices in the genistein treated cells
Yamaguchi et al., Mol Cell Biol 2006 : Thapsigargin ( THG ) is an inhibitor of the endoplasmic reticulum Ca2+-ATPase that induces caspase 3 activation and apoptosis in HCT116 cells through a Bax dependent pathway
Das et al., Brain Res 2008 (Brain Neoplasms...) : Besides, apoptosis was associated with alterations in expression of pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins resulting in an increase in Bax : Bcl-2 ratio, mitochondrial release of cytochrome c and Smac, downregulation of selective baculoviral inhibitor-of-apoptosis repeat containing ( BIRC ) molecules, an increase in intracellular free [Ca2+ ], and activation of calpain and caspase-3
Chen et al., Meat Sci 2011 : Effects of camptothecin, etoposide and Ca2+ on caspase-3 activity and myofibrillar disruption of chicken during postmortem ageing
Wang et al., Nutr Cancer 2012 (Calcium Signaling...) : Exposure to DATS additionally induced endogenous endoplasmic reticulum stress markers and intracellular Ca2? mobilization, upregulation of Bip/GRP78 and CHOP/GADD153, and activation of caspase-4