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IL1B — STAT1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Tian et al., J Immunol 2000
(Carcinoma, Hepatocellular) :
IL-1 beta attenuates IFN-alpha beta induced antiviral activity and
STAT1 activation in the liver : involvement of proteasome dependent pathway ... Furthermore,
IL-1beta attenuated IFN-alphabeta induced
STAT1 binding and tyrosine phosphorylation without affecting the level of STAT1 protein
Shen et al., Biochem J 2000
:
Furthermore,
IL-1beta selectively
down-regulated the IL-6 induced tyrosine phosphorylation of
STAT1 without affecting the level of STAT1 or tyrosine phosphorylation of STAT3 ... However, pretreatment with the proteasome inhibitor MG132 under conditions that prevented the IL-1beta dependent activation of the nuclear factor NF-kappaB also blocked the inhibitory
effect of
IL-1beta on IL-6 activated
STAT1 ... In related experiments, the protein tyrosine phosphatase inhibitor Na ( 3 ) VO ( 4 ) also antagonized the inhibitory
effect of
IL-1beta on the activation of
STAT1 by IL-6
Badgwell et al., Surgery 2002
(Escherichia coli Infections...) :
The 2 groups of mice were analyzed for serum levels of interferon-gamma, tumor necrosis factor-alpha, and
interleukin-1beta as well as
activation of NFkappaB and
STAT1 , 2 proinflammatory transcription factors
Yang et al., J Biol Chem 2004
:
This activity of IL-1beta does not depend on
IL-1beta dependent
STAT1-serine phosphorylation but on NF-kappaB dependent gene induction
Joshi et al., J Interferon Cytokine Res 2006
:
A
role for
Stat1 in the regulation of lipopolysaccharide induced
interleukin-1beta expression ... Although both interferon-beta (IFN-beta) and IFN-gamma activate Stat1, the early appearance of IFN-beta in the circulation after LPS administration suggested its pivotal role in
Stat1 mediated
IL-1beta expression in vivo
Kanda et al., Endocrinology 2008
:
IL-1beta induced serine phosphorylation of inhibitory kappaBalpha,
STAT1 , and STAT3
Ravichandran et al., Indian J Exp Biol 2011
(Carcinoma...) :
Detailed molecular analyses showed that
IL-1beta increased expression of phosphorylated
STAT1 ( Tyr701 and Ser727 ) and STAT3 ( Tyr705 and Ser727 ) both in total cell lysates and nuclear lysates
Rohn et al., J Immunol 1999
(Astrocytoma) :
IL-1beta did not interfere with IFN-gamma receptor signal transduction, since tyrosine phosphorylation, nuclear translocation, and DNA binding of
STAT-1alpha to an IFN-gamma activation sequence of the type IV CIITA promoter were not
affected by
IL-1beta