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AKT1 — CTNNB1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Yuan et al., J Biol Chem 1999
:
We investigated the
effect of an activated
Akt on the accumulation of cytosolic
beta-catenin and LEF-1 dependent transcription ... Although the activated
Akt , mAkt, clearly inhibited the kinase activity of GSK, mAkt alone did not
induce accumulation of cytosolic
beta-catenin or activate LEF-1 dependent transcription
Sharma et al., J Biol Chem 2002
(Prostatic Neoplasms) :
Phosphatidylinositol
3-kinase/Akt stimulates androgen pathway through GSK3beta inhibition and nuclear
beta-catenin accumulation
Tian et al., Proc Natl Acad Sci U S A 2004
:
More importantly, 14-3-3zeta facilitates
activation of
beta-catenin by the survival kinase
Akt and colocalizes with activated Akt in intestinal stem cells
Tian et al., Cell cycle (Georgetown, Tex.) 2005
:
Thus,
Akt may
contribute to activation of
beta-catenin in ISCs in coordination with Wnt signaling ... By conducting a proteomic analysis of the beta-catenin complex, we show that 14-3-3zeta exists in the beta-catenin complex and facilitates
activation of
beta-catenin by
Akt , which, intriguingly, appears to be predominantly in ISCs
Dash et al., Cell Signal 2005
:
We suggest that the
Akt mediated
activation of
beta-catenin leads to inhibition of trophoblast apoptosis following increased expression of iNOS
Dihlmann et al., Carcinogenesis 2005
(Colonic Neoplasms...) :
Regulation of
AKT1 expression by
beta-catenin/Tcf/Lef signaling in colorectal cancer cells ... Accordingly, we hypothesized that
AKT1 expression might be
regulated by
Wnt/beta-catenin signaling
Abbosh et al., Thyroid 2005
(Thyroid Neoplasms) :
Activation of
AKT by phosphatidylinositide-3 kinase (PI3K), a RAS effector,
results in GSK3beta phosphorylation and deactivation and subsequent
beta-catenin upregulation in thyroid cancer
Almeida et al., J Biol Chem 2005
:
Wnt3a induced phosphorylation of GSK-3beta and downstream activation of
beta-catenin mediated transcription
required ERK, PI3K, and
Akt signaling
Ishibe et al., Mol Cell Biol 2006
:
In nonconfluent cells treated with HGF, the high level of
Akt activation
resulted in inhibitory phosphorylation of glycogen synthase kinase 3beta ( GSK-3beta ) and increased
beta-catenin nuclear signaling
Fang et al., J Biol Chem 2007
(Neoplasm Invasiveness...) :
AKT mediated phosphorylation of
beta-catenin causes its disassociation from cell-cell contacts and accumulation in both the cytosol and the nucleus and enhances its interaction with 14-3-3zeta via a binding motif containing Ser552 ... Phosphorylation of beta-catenin by AKT increases its transcriptional activity and promotes tumor cell invasion, indicating that
AKT dependent regulation of
beta-catenin plays a critical role in tumor invasion and development
LaMarca et al., Hum Reprod 2008
:
Although
Akt activation
leads to GSK-3beta phosphorylation and the subsequent expression of
beta-catenin , activation of this pathway by 1-azakenpaullone was insufficient to stimulate the motile phenotype
Chung et al., J Endocrinol 2008
:
Our data also suggest that
PI3K/Akt mediated inactivation of GSK-3beta and stabilization of
beta-catenin contribute to the anti-apoptotic effects of ghrelin
Siler et al., Virology 2008
:
The nuclear translocation, but not accumulation of
beta-catenin was
dependent on
Akt activation
Bedel et al., Circ Res 2008
(Atherosclerosis...) :
The concomitant phosphatidylinositol
3-kinase/Akt activation and glycogen synthase kinase 3-beta phosphorylation
induced the inhibition of the proteasomal degradation of
beta-catenin
Espada et al., J Cell Physiol 2009
:
This protective effect is associated with
beta-catenin dependent transcription and with activation of survival factor
Akt/PKB
Hong et al., J Exp Clin Cancer Res 2009
(Carcinoma, Squamous Cell...) :
This study aimed to investigate whether
Akt inhibition would
restore the expression of E-cadherin and
beta-catenin , reduce that of Vimentin, and induce the MErT in OSCC cells with low or negative expression of E-cadherin
Saegusa et al., Am J Pathol 2009
(Carcinosarcoma...) :
In endometrial cancer cell lines, active
Akt induced the stabilization of nuclear
beta-catenin through the phosphorylation of GSK-3beta, and this, in turn, led to the transactivation of Slug, which was mediated by nuclear beta-catenin
Lee et al., Stem Cells 2009
:
BMP-4 induced
beta-catenin activation and cyclin D1 expression were
attenuated by phosphatidyl inositol 3-kinase (PI3K) siRNA and
Akt inhibitor
Wang et al., J Am Soc Nephrol 2009
:
Because Akt regulates Bax, we examined the
effects of the
beta-catenin mutants on
Akt expression and activation ... Constitutively active beta-catenin increased Akt-1 expression and activation before and after stress, and treatment with a phosphatidylinositol-3 kinase inhibitor antagonized the protective
effects of
beta-catenin on
Akt activation, Bax inhibition, and cell survival
Xia et al., Mol Cell Biol 2010
:
Interestingly, the activation of PI3K/Akt appeared to be independent of the activation of PKA, whereas both
PI3K/Akt and PKA signaling inactivated GSK-3 and
increased beta-catenin translocation
Robertson et al., Exp Cell Res 2010
(Prostatic Neoplasms) :
Osteopontin
induces beta-catenin signaling through activation of
Akt in prostate cancer cells
Sunters et al., J Biol Chem 2010
:
Mechano-transduction in osteoblastic cells involves strain regulated estrogen receptor alpha mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol
3-kinase/AKT dependent Wnt/LRP5 receptor independent activation of
beta-catenin signaling ... These data suggest an initial cascade of strain related events in osteoblasts in which strain activates IGF-IR, in association with ERalpha, so initiating phosphatidylinositol
3-kinase/AKT dependent activation of
beta-catenin and altered lymphoid enhancing factor/T cell factor transcription
Venkatesan et al., Cell Signal 2010
:
Further, WISP1 stimulates
PI3K-Akt dependent GSK3beta phosphorylation and
beta-catenin nuclear translocation
Wang et al., J Bone Miner Res 2010
:
T ( 3 ) -mediated Wnt-4 expression,
beta-catenin activation, cell proliferation, and terminal differentiation of growth plate chondrocytes are partially
prevented by the IGF1R inhibitor picropodophyllin as well as by the
PI3K/Akt signaling inhibitors LY294002 and Akti1/2
Nava et al., Immunity 2010
(Colitis) :
Short-term exposure of intestinal epithelial cells to IFN-gamma resulted in
activation of
beta-catenin through
AKT , followed by induction of the secreted Wnt inhibitor Dkk1
Lee et al., Gastroenterology 2010
(Colitis...) :
We investigated whether phosphoinositide 3-kinase (PI3K) is required for
Akt mediated activation of
beta-catenin during intestinal inflammation ... Biochemical analyses indicated that
PI3K-Akt signaling
increased nuclear total
beta-catenin and P-beta-catenin ( 552 ) levels and reduced N-terminal beta-catenin phosphorylation, which is associated with degradation
Zhang et al., Neural development 2013
:
AKT activation by N-cadherin
regulates beta-catenin signaling and neuronal differentiation during cortical development