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EPHB2 — FSHR

Text-mined interactions from Literome

Piketty et al., Reproductive biology and endocrinology : RB&E 2006 : Upon FSH stimulation, the FSH-R activates the extracellular signal regulated kinases ( ERK ) ... In the present study, we examined the ability of the FSH activated FSH-R to induce ERK phosphorylation, in conditions where its beta-arrestin- and dynamin mediated internalization was impaired ... From these results, we conclude that the FSH-R does not require beta-arrestin- nor dynamin mediated internalization to initiate ERK phosphorylation in response to FSH
Kara et al., Mol Endocrinol 2006 : Here, we show that the FSH-R expressed in HEK 293 cells activated ERK by two temporally distinct pathways dependent, respectively, on Galpha ( s ) /PKA and beta-arrestins ... G protein coupled receptor kinase 5 ( GRK5 ) and GRK6 were required for beta-arrestin dependent ERK activation by both the wild-type and 5A FSH-R ... In conclusion, we demonstrate the existence of a beta-arrestin dependent, GRK regulated mechanism for ERK activation by the FSH-R