Ishizuka et al., J Pharmacol Exp Ther 2008
:
Inhibition of NF-kappaB activation and inhibition of ERK1/2 phosphorylation inhibited 20-HETE induced ICAM expression
Zennadi et al., Blood 2012
(Anemia, Sickle Cell...) :
These results demonstrate that ERK activation induces phosphorylation of cytoskeletal proteins and the adhesion molecule ICAM-4 , promoting SS RBC adhesion to the endothelium