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PPARD — PTGS2

Text-mined interactions from Literome

Glinghammar et al., Biochem Biophys Res Commun 2003 (Carcinoma, Hepatocellular...) : PPARdelta activation induces COX-2 gene expression and cell proliferation in human hepatocellular carcinoma cells ... In this work, we have studied the effect of PPARdelta activation on COX-2 expression using a selective agonist ( GW501516 ) in human hepatocellular carcinoma ( HepG2 ) cells ... We conclude that PPARdelta activation in HepG2 cells results in induced COX-2 expression and increased cellular proliferation
Fauti et al., FEBS J 2006 : In agreement with this conclusion, the overexpression of ectopic Cox-2 and PGI2 synthase (PGIS) resulted in massive PGI2 synthesis but did not activate the transcriptional activity of PPARbeta
Xu et al., J Biol Chem 2006 (Bile Duct Neoplasms...) : Taken together, these observations reveal that PPARdelta induces COX-2 expression in human cholangiocarcinoma cells and that the COX-2 derived PGE2 further activates PPARdelta through phosphorylation of cPLA2alpha
Xu et al., Cancer Res 2006 (Carcinoma, Hepatocellular...) : Thus, PPARdelta induces COX-2 expression and the COX-2 derived PGE ( 2 ) further activates PPARdelta via cPLA(2)alpha
Wu et al., Methods Mol Biol 2009 (Colonic Neoplasms) : Furthermore, the COX-2 inhibitors suppress PPARdelta expression
Konger et al., PPAR research 2010 : In this current study, we demonstrate that PPARgamma agonists, but not PPARalpha or PPARbeta/delta agonists, induce PGE ( 2 ) production and COX-2 expression in primary human keratinocytes ( PHKs )