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PTPN11 — SOAT1

Text-mined interactions from Literome

Kamimura et al., Rev Physiol Biochem Pharmacol 2003 (Acute-Phase Reaction...) : Intriguingly, recent in vivo studies indicated that the SHP-2 binding site- and YXXQ mediated pathways through gp130 are not mutually exclusive but affect each other : a mutation at the SHP-2 binding site prolongs STAT3 activation, and a loss of STAT activation by gp130 truncation leads to sustained SHP-2/ERK MAPK phosphorylation
Pai et al., Biochem Biophys Res Commun 2005 (Stomach Neoplasms) : While JAK inhibition with AG490 significantly reduced leptin induced ERK2, STAT3 phosphorylation, and cell proliferation, SHP2 inhibition only partially reduced cancer cell proliferation
Kim et al., J Biol Chem 2006 : Based on our previous finding that in cultured rat brain microglia, gangliosides induce rapid and transient activation of the JAK-STAT pathway, we hypothesized that raft mediated SHP-2 activation is involved in transient activation of JAK-STAT signaling by gangliosides
Jia et al., PloS one 2010 : In addition, NS1 expression induces up-regulation of the JAK/STAT inhibitors, SOCS1 and SOCS3
Servidei et al., J Biol Chem 1998 : Coordinate regulation of STAT signaling and c-fos expression by the tyrosine phosphatase SHP-2