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BCL2 — RELA

Pathways - manually collected, often from reviews:

• KEGG Apoptosis: NFKB1/RELA → BCL2 (gene expression, expression)
• KEGG Pathways in cancer: NFKB1/NFKB2/RELA → BCL2 (gene expression, expression)
• KEGG Prostate cancer: NFKB1/RELA → BCL2 (gene expression, expression)

Text-mined interactions from Literome

Badrichani et al., J Clin Invest 1999 : In addition, Bcl-2 or Bcl-XL inhibits activation of NF-kappaB and thus upregulation of proinflammatory genes ... Bcl-2 mediated inhibition of NF-kappaB in EC occurs upstream of IkappaBalpha degradation without affecting p65 mediated transactivation
Tamatani et al., J Biol Chem 1999 : Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons ... Expression of the mutant NFkappaB completely inhibited NFkappaB DNA binding activity and inhibited both TNF induced up-regulation of Bcl-2 and Bcl-x expression and neuroprotective effect
Maulik et al., Ann N Y Acad Sci 1999 (Myocardial Ischemia...) : In concert, the adapted myocardium is associated with increased antioxidant gene Bcl-2 , increased binding activity of the nuclear transcription factor NF kappa B , and reduced binding activity of AP-1 compared to nonadapted hearts
Zheng et al., J Immunol 2000 : Transduced Bcl-2 did not reduce TNF mediated NF-kappaB activation or constitutive expression of class I MHC molecules
Tamatani et al., J Neurochem 2000 : These findings suggest a pathway where NFkappaB activation induces overexpression of Bcl-2 and Bcl-x, which function to prevent apoptotic cell death following H/R treatments
Bertin et al., J Biol Chem 2000 : Although its role in apoptosis remains to be determined, BCL10 likely activates NF-kappaB through the IKK complex in response to upstream stimuli
Kirshenbaum et al., Clin Invest Med 2000 : Moreover, the Bcl-2 mediated NFkappaB activation was found to be related to changes in the activity of the NFkappaB regulatory protein IkappaBalpha ( inhibitor of kappa beta )
Sasaki et al., Antioxid Redox Signal 1999 (Myocardial Ischemia...) : Ischemic adaptation attenuates apoptotic cell death, further increases NF-kappaB binding activity and Bcl-2 gene induction , but reduces AP-1 binding activity
Kanai et al., Gastroenterology 2001 : TGF-alpha also enhanced the expression of Bcl-2 family proteins in an NF-kappaB dependent manner
Kurland et al., J Biol Chem 2001 : We investigated the role of NF-kappaB1 ( p50 ) homodimers in the expression of Bcl-2 in two murine B-cell lymphoma cell lines : LY-as, an apoptosis-proficient line with low Bcl-2 protein expression and no nuclear NF-kappaB activity, and LY-ar, a nonapoptotic line with constitutive p50 homodimer activity and 30 times more Bcl-2 protein expression than LY-as
Heckman et al., Oncogene 2002 (Lymphoma...) : NF-kappaB activates Bcl-2 expression in t ( 14 ; 18 ) lymphoma cells ... Conflicting evidence exists on the effects of NF-kappaB expression on Bcl-2 levels in different cell types
Regula et al., J Biol Chem 2002 (MAP Kinase Signaling System) : IKK beta is required for Bcl-2 mediated NF-kappa B activation in ventricular myocytes ... The underlying mechanism by which Bcl-2 activates NF-kappa B is undefined ... In view of growing evidence that the I kappa B kinases ( IKKs ), notably IKK beta, are involved in signal induced phosphorylation of I kappa B alpha, we ascertained whether IKK beta is necessary and sufficient for Bcl-2 mediated NF-kappa B activation ... Here we demonstrate that expression of Bcl-2 in ventricular myocytes resulted in an increase in NF-kappa B-dependent DNA binding, NF-kappa B gene transcription and reduced I kappa B alpha levels ... Catalytically inactive mutants of IKK beta, but not IKK alpha, suppressed Bcl-2 mediated I kappa B alpha phosphorylation and NF-kappa B activation ... Transfection of human embryonic 293 cells with a kinase-defective Raf-1 or a kinase-defective mitogen activated protein kinase/extracellular signal regulated kinase kinase-1 ( MEKK-1 ) suppressed Bcl-2 mediated IKK beta activity and NF-kappa B activation ... Further, Bcl-2 mediated NF-kappa B activity was impaired in nullizygous mouse embryonic fibroblasts deficient for IKK beta
Chendil et al., Cancer Biol Ther 2002 (Prostatic Neoplasms) : Exposure of PC-3 cells to Ad5-I kappa B super-repressor inhibited radiation induced Bcl-2 expression indicating that radiation induced NF kappa B activity is required for the induction of Bcl-2 protein
Fujioka et al., Oncogene 2003 (Adenocarcinoma...) : Inhibiting NF-kappa B signaling by expressing I kappa B alpha M significantly reduced expression of Bcl-x ( L ) and Bcl-2
Zheng et al., J Exp Med 2003 : Our results further indicate that NF-kappaB regulates TCR induced expression of antiapoptotic Bcl-2 family members
Kurland et al., J Biol Chem 2003 (Lymphoma, B-Cell) : In a previously published report ( Kurland, J. F., Kodym, R., Story, M. D., Spurgers, K. B., McDonnell, T. J., and Meyn, R. E. ( 2001 ) J. Biol. Chem. 276, 45380-45386 ), we described the NF kappa B status for two murine B-cell lymphoma cell lines, LY-as ( apoptosis-sensitive ) and LY-ar ( apoptosis-refractory ) and provided evidence that NF kappa B1 ( p50 ) homodimers contribute to the expression of Bcl-2 in the LY-ar line
Massaad et al., Neuroreport 2003 : Bcl-2 phosphorylation is not required for its effects on NFkappaB activity ... To study whether effects on NFkappaB are part of the Bcl-2 anti-apoptotic mechanism, we examined the effect of Bcl-2 on NFkappaB transcriptional activity in PC12 cells and determined the role thereby of Bcl-2 phosphorylation ( required for the anti-apoptotic function of Bcl-2 ) ... We conclude that such Bcl-2 effect on NFkappaB activity is distinct from its anti-apoptotic action
Viatour et al., Leukemia 2003 (Breast Neoplasms...) : NF- kappa B2/p100 induces Bcl-2 expression
Yorke et al., Eur J Cancer 2003 (Adenocarcinoma...) : Receptor activator of NF-kappaB ( RANK ) activation induces several survival signals including nuclear factor kappaB (NF-kappaB) and activation and upregulation of Bcl-xL
Prendes et al., J Immunol 2003 : The absence of RelA significantly reduced mRNA expression of the antiapoptotic genes cellular FLICE-inhibitory protein and Bcl-2
Misra et al., Circulation 2003 (Myocardial Infarction...) : These studies suggest that the cytoprotective effects of NF-kappaB are mediated , at least in part, by Bcl-2 or c-IAP1
Arnold et al., Neuroimmunomodulation 2004 (Lymphoma) : Western blot analysis detected an increase in Bcl-2 while the levels of nuclear factor kappa B (NFkappaB) remained unchanged in GHo cells
Song et al., Neurosci Res 2004 : However, overexpression of Bcl-2 reduced Abeta induced apoptosis, and suppressed the activation of p38 MAP kinase and NF-kappaB ... Moreover, inhibition of NF-kappaB activation by sodium salicylates reduced Abeta induced apoptosis and activation of p38 MAP kinase, and up regulated Bcl-2 expression
Shukla et al., Neoplasia (New York, N.Y.) 2004 (Adenocarcinoma...) : The nuclear levels of NF-kappaB/p65 correlated with concurrent increase in cytosolic levels of IkappaBalpha along with NF-kappaB dependent expression of Bcl2 , cyclin D1, MMP-9, and VEGF
Chen et al., Apoptosis 2004 (Colonic Neoplasms) : Bcl-2, and to the less extent, Bcl-xL , were able to increase the activity of NF-kappa B , which was a known anti-apoptotic molecule in human colon cancer cells
Tran et al., J Biol Chem 2005 (Astrocytoma...) : In addition, Fn14 activation induced BCL-XL and BCL-W mRNA and protein levels, and this effect was dependent upon NFkappaB transcriptional activity ... Our results suggest that NFkappaB mediated up-regulation of BCL-XL and BCL-W expression in glioma cells increases cellular resistance to cytotoxic therapy induced apoptosis
Akita et al., Virology 2005 : p21WAF1 modulates NF-kappaB signaling and induces anti-apoptotic protein Bcl-2 in Tax expressing rat fibroblast
Pozo-Guisado et al., Int J Cancer 2005 : NF-kappaB , a regulator of Bcl-2 expression, and calpain protease activity, a regulator of NF-kappaB, were both inhibited by RES
Fahy et al., Cancer Chemother Pharmacol 2005 (Breast Neoplasms...) : The effect of mutation of a NF-kappaB site in the BCL-2 promoter was determined, as was the effect of inhibition of NF-kappaB function using a 26S proteasome inhibitor ( bortezomib ) on both BCL-2 transcription and induction of apoptosis
Tracey et al., J Pathol 2005 (Leukemia, Lymphocytic, Chronic, B-Cell...) : Meanwhile, in chronic lymphocytic leukaemia ( CLL ) -derived lymphocytes, NF-kappaB inhibition resulted in a marked decrease in BCL2 expression
Hu et al., J Clin Invest 2006 (Lymphoma, B-Cell, Marginal Zone...) : Furthermore, BCL10 and cIAP2-MALT1 synergistically activate NF-kappaB
Tao et al., Mol Cell Biol 2006 : Up-regulation of proapoptotic protein Bcl-XS and neuronal apoptosis induced by serum deprivation are blocked by inhibition and/or down-regulation of NF-kappaB and by prevention of K+ loss
Choi et al., Experimental biology and medicine (Maywood, N.J.) 2006 (Hyperoxia...) : These results indicate that hyperoxia induces myocardial tolerance against ischemia-reperfusion injury in association with Bcl-2 induction by NF-kappaB activation through reactive oxygen species and PKC dependent signaling pathway
Kooncumchoo et al., J Mol Neurosci 2006 (Parkinson Disease) : In this study we have determined the neuroprotective role of coenzyme Q ( 10 ) ( CoQ ( 10 ) ) in ironinduced apoptosis in cultured human dopaminergic ( SK-N-SH ) neurons, in metallothionein gene- manipulated mice, and in alpha-synuclein knockout ( alpha-synko ) mice with a primary objective to assess a possible therapeutic and anti-inflammatory potential for CoQ ( 10 ) in PD. Iron induced mitochondrial damage and apoptosis were characterized by reactive oxygen species production, increased metallothionein and glutathione synthesis, caspase- 3 activation, NF-kappaB induction , and decreased Bcl-2 expression, without any significant change in Bax expression
Khanbolooki et al., Mol Cancer Ther 2006 (Pancreatic Neoplasms) : NF-kappaB inhibition resulted in down-regulation of BCL-XL and XIAP, and silencing either restored TRAIL sensitivity in TRAIL-resistant cells
Karmakar et al., Apoptosis 2007 (Neuroblastoma) : Apoptosis was associated with an increase in [ Ca ( 2+ ) ] ( i ), increase in Bax : Bcl-2 ratio, mitochondrial release of cytochrome c, increase in cytosolic Smac/Diablo, and down regulation of inhibitor-of-apoptosis proteins and nuclear factor kappa B (NFkappaB)
Deeb et al., J Pharmacol Exp Ther 2007 (Prostatic Neoplasms) : Because expression of antiapoptotic Bcl-2, Bcl-xL , and X-chromosome linked inhibitor of apoptosis protein ( XIAP ) is regulated by NF-kappaB , both curcumin and SH-6 decreased the levels of these proteins in PC3 cells through inhibition of NF-kappaB ... Because expression of antiapoptotic Bcl-2 , Bcl-xL, and X-chromosome linked inhibitor of apoptosis protein ( XIAP ) is regulated by NF-kappaB , both curcumin and SH-6 decreased the levels of these proteins in PC3 cells through inhibition of NF-kappaB
Kunnumakkara et al., Cancer Res 2007 (Neovascularization, Pathologic...) : In vivo, tumors from nude mice injected with pancreatic cancer cells and treated with a combination of curcumin and gemcitabine showed significant reductions in volume ( P = 0.008 versus control ; P = 0.036 versus gemcitabine alone ), Ki-67 proliferation index ( P = 0.030 versus control ), NF-kappaB activation , and expression of NF-kappaB regulated gene products ( cyclin D1, c-myc, Bcl-2, Bcl-xL , cellular inhibitor of apoptosis protein-1, cyclooxygenase-2, matrix metalloproteinase, and vascular endothelial growth factor ) compared with tumors from control mice treated with olive oil only ... In vivo, tumors from nude mice injected with pancreatic cancer cells and treated with a combination of curcumin and gemcitabine showed significant reductions in volume ( P = 0.008 versus control ; P = 0.036 versus gemcitabine alone ), Ki-67 proliferation index ( P = 0.030 versus control ), NF-kappaB activation, and expression of NF-kappaB regulated gene products ( cyclin D1, c-myc, Bcl-2 , Bcl-xL, cellular inhibitor of apoptosis protein-1, cyclooxygenase-2, matrix metalloproteinase, and vascular endothelial growth factor ) compared with tumors from control mice treated with olive oil only
Takase et al., Kidney Int 2008 (Chronic Disease...) : Inhibition of NF-kappaB dependent Bcl-xL expression by clusterin promotes albumin induced tubular cell apoptosis
Lee et al., Int J Cancer 2008 (Carcinoma, Squamous Cell...) : A signal network involving coactivated NF-kappaB and STAT3 and altered p53 modulates BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas
Aimbire et al., Int Immunopharmacol 2008 (Inflammation) : LLLT and an inhibitor of NF-kappaB nuclear translocation ( BMS 205820 ) attenuated the mRNA levels of Bcl-xL and A1 mRNA in lung neutrophils obtained from mice subjected to LPS induced inflammation
Iyer et al., Cell Microbiol 2008 (Leukemia, Myeloid) : L. reuteri downregulated nuclear factor-kappaB (NF-kappaB) dependent gene products that mediate cell proliferation ( Cox-2, cyclin D1 ) and cell survival ( Bcl-2 , Bcl-xL )
Ghosh-Choudhury et al., Breast Cancer Res Treat 2009 (Adenocarcinoma...) : NFkappaB DNA binding activity and NFkappaB dependent transcription of Bcl-2 and Bcl-XL genes were also prevented by DHA and EPA treatment ... NFkappaB DNA binding activity and NFkappaB dependent transcription of Bcl-2 and Bcl-XL genes were also prevented by DHA and EPA treatment ... Finally, we showed that PTEN expression significantly inhibited NFkappaB dependent transcription of Bcl-2 and Bcl-XL genes ... Finally, we showed that PTEN expression significantly inhibited NFkappaB dependent transcription of Bcl-2 and Bcl-XL genes
Marrero et al., Brain Res 2009 (Inflammation) : In this study, we investigated the effects of inhibiting the alpha7 nAChR-JAK2 pro-survival cascade on the nicotine induced production of the survival factor Bcl-2 and the transcriptional activation of NF-kappaB , AP-1, STAT1, STAT3, and STAT5
Kim et al., Arch Pharm Res 2009 (Colonic Neoplasms) : NF-kappaB target gene expression of apoptotic cell death proteins ( Bax, caspase-3, caspase-9 ) was significantly enhanced, but the expression of anti-apoptotic genes and cell proliferation marker genes ( Bcl-2 , inhibitor of apoptosis protein ( IAP-1 ) and X chromosome IAP (XIAP), Cox-2, c-Fos, c-Jun and cyclin D1 ) was significantly inhibited by the combined treatment compared to Rg3 or docetaxel alone
Banerjee et al., Cancer Res 2009 (Pancreatic Neoplasms) : Our data provide mechanistic evidence for the first time showing that DIM potentiates the killing of pancreatic cancer cells by down-regulation of constitutive as well as drug induced activation of NF-kappaB and its downstream genes ( Bcl-xL , XIAP, cIAP, and survivin )
Nehra et al., FASEB J 2010 (Breast Neoplasms) : NF-kappaB inhibition restores the ability of 4HT to decrease BCL2 expression, increase mitochondrial membrane permeability, and induce a caspase dependent apoptotic cell death in resistant cells
Liu et al., J Biol Chem 2010 : Overall, our results suggest that AMPKalpha1, but not AMPKalpha2 activation, promotes cell survival by increasing NF-kappaB mediated expression of anti-apoptotic proteins ( Bcl-2 and Survivin ) and intracellular ATP contents
Priyadarsini et al., Free radical research 2010 : Altered expression of the Bcl-2 family of proteins, inhibition of NF-kappaB activation and over-expression of caspases and survivin provide compelling evidence that azadirachtin and nimbolide induce a shift of balance toward a pro-apoptotic phenotype
Huang et al., Biomaterials 2010 (Melanoma) : Further results demonstrated that the upregulation of anti-apoptotic molecules Bcl-2 expression and the inhibition of NF-kappaB activation by MSNs may promote cell proliferation in a redox-sensitive signal pathway
Jinawath et al., PloS one 2010 (Ovarian Neoplasms) : Combined ectopic expression of RELA and STAT5B enhanced Bcl-xL promoter activity while treatment with BMS-345541 and Dasatinib decreased it
Wang et al., Microb Pathog 2010 : Because expressions of anti-apoptotic Bcl-2 , survivin, inhibition of apoptosis protein ( cIAP ), and X-chromosome linked inhibitor of apoptosis protein ( XIAP ) are regulated by NF-kappaB , S. aureus decreased the levels of these proteins in U937 cells through inhibition of NF-kappaB
Coscia et al., Leukemia 2011 (Leukemia, Lymphocytic, Chronic, B-Cell) : Nuclear factor-kB (NF-kB) was rapidly inactivated, and B-cell leukemia/lymphoma 2 (Bcl-2) expression progressively down-regulated in the UM CLL B cells
Wang et al., J Chemother 2012 (Breast Neoplasms) : Our results showed that TNF-alpha treatment increased Bcl-2 mRNA and protein levels in breast cancer cells, suggesting that Bcl-2 is directly regulated by nuclear factor-kappaB (NF-kappaB) in response to TNF-alpha
Zhang et al., Mol Cell Biol 1994 (Leukemia, Lymphocytic, Chronic, B-Cell...) : In contrast to I kappa B alpha ( MAD3 ), BCL3 does not cause NF-kappa B p50 to be retained in the cytoplasm ; instead, in cotransfection assays, it alters the subnuclear localization of p50
Lin et al., J Cell Biol 1995 (Neuroblastoma...) : Understanding the precise mechanism by which Bcl-2 and thiol agents inhibit SV-induced nuclear NF-kappa B activity in AT-3 cells may provide insights into the pluripotent antiapoptotic actions of these agents
Grimm et al., J Cell Biol 1996 : Bcl-2 inhibited NF-kappaB activity by an unusual mechanism
de Moissac et al., J Biol Chem 1998 : Bcl-2 activates the transcription factor NFkappaB through the degradation of the cytoplasmic inhibitor IkappaBalpha
Ivanov et al., Int Immunol 1998 : Furthermore, Bcl-2 prevented Dex induced RelA-p50 activation