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CCNH — PCNA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Lee et al., Curr Biol 1999
:
Cdc2-cyclin complexes isolated from the arrested cells could be
activated in vitro by recombinant
CAK , whereas complexes from wild-type cells or either of the single mutants were refractory to activation
Rank et al., Biochem Biophys Res Commun 2000
:
A synthetic peptide, ACRRLFGPVDSE, from the N-terminal residues 17-28 of p21, was also a potent inhibitor of
CAK mediated
cdk2/cyclin E phosphorylation
Kim et al., J Biol Chem 2001
:
For example, CDK9 was not phosphorylated by CAK, whereas
CDK2-cyclin A kinase activity was dramatically
enhanced by
CAK
Brabazon et al., Biochim Biophys Acta 2002
:
Cyclin dependent kinase 8 (cdk8) regulates transcription by phosphorylating RNA polymerase II and
TFIIH
Nigg et al., Ciba Found Symp 1992
:
Regulation of
p34cdc2 protein kinase activity by phosphorylation and
cyclin binding
Meijer et al., EMBO J 1991
:
We have investigated the
role of
cyclin in the formation of this complex and the tyrosine phosphorylation of
p34cdc2 , using highly synchronous mitotic sea urchin eggs as a model
Parker et al., EMBO J 1991
:
Cyclin promotes the tyrosine phosphorylation of
p34cdc2 in a wee1+ dependent manner
Solomon et al., Cell 1990
:
Cyclin activation of
p34cdc2 ... The gradual accumulation of
cyclin in the frog egg
induces an abrupt and concerted activation of
p34cdc2 that initiates mitosis
Pavlová et al., Anim Reprod Sci 2013
:
The accumulation of markers of proliferation ( cyclin B1 and
cyclin dependent protein kinase
Cdc2/p34 ) and proteins p50, p65 and SIRT1 in the cells was detected by using SDS-PAGE/Western immunoblotting and immunocytochemistry
Solomon et al., EMBO J 1993
:
The mitotic inducer
p34cdc2 requires association with a
cyclin and phosphorylation on Thr161 for its activity as a protein kinase
Ladner et al., J Biol Chem 1996
:
The amino acid context of this phosphorylation site corresponds to the consensus target sequence for the
cyclin dependent protein kinase
p34 ( cdc2 )
Kwon et al., Gene 1996
:
p27Kip1 directly inhibits the catalytic activity of cyclin/cdks ( cyclin dependent kinase ) complexes and/or interferes physically with
cyclin/cdks activation by
CAK
Nishijima et al., J Cell Biol 1997
:
Such an in vitro
activation of
p34 ( cdc2 )
/cyclin B, however, did not occur in the extract prepared from cells pretreated with protein synthesis inhibitor cycloheximide, although this extract still retained the ability to inhibit p34 ( cdc2 ) /cyclin B activation