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EGF — LEP

Text-mined interactions from Literome

Jamroz-Wiśniewska et al., Biochem Pharmacol 2008 (Hypertension) : Leptin , administered in increasing doses ( 0.1-0.5 mg/kg/day ) for 10 days, increased phosphorylation levels of non-receptor tyrosine kinase, c-Src, EGF receptor and extracellular signal regulated kinases ( ERK ) in aorta and kidney, which was accompanied by the increase in plasma concentration and urinary excretion of isoprostanes and H2O2
Cascio et al., J Cell Physiol 2009 (Colorectal Neoplasms) : Here we investigated the molecular mechanism by which leptin and VEGF expression are regulated in colon cancer by epidermal growth factor (EGF) ... In colon cancer cell line HT-29, EGF induced the binding of signal transducer and activator transcription 3 ( STAT3 ) to STAT3 consensus motifs within the VEGF and leptin promoters and stimulated leptin and VEGF mRNA and protein synthesis