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IRF6 — MNAT1

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Vaidyanathan et al., Cytokine 2001 : Despite comparable levels of total p35 mRNA, LPS induced p35 exon 1 transcripts led to significantly more bioactive IL-12 from SAC than IFN-gamma/CD40 induced exon 1a/exon 2 transcripts as measured by ELISA
Yoshiura et al., Immunogenetics 2003 : In the spleen and head kidney, expression of IL-12 p35 was induced by polyriboinosinic polyribocytidylic acid [ poly ( I:C ) ] and not by lipopolysaccharide (LPS) , while expression of IL-12 p40 was constitutive and unresponsive to both poly ( I:C ) and LPS
Liu et al., J Exp Med 2003 : We demonstrate that the levels of IL-12 p35 protein stimulated by IFN-gamma and lipopolysaccharide (LPS) correspond to those of its mRNA, and that the nuclear factor kappaB signaling pathway is essential for the induction of IL-12 p35 transcription by LPS
Nakano et al., Blood 2007 (Bacterial Infections...) : The transcription levels of p35 and p40 were increased by stimulation of BMMCs with IFN-gamma/lipopolysaccharide (LPS)
Qi et al., Sci China C Life Sci 2000 : Taken together, the data suggest : ( i ) IFN-gamma/LPS could strongly induce the expression of IL-12 p40 and p35 mRNA ; both the expression levels were equal ; this phenomenon coincided with the high-level secretion of IL-12 p70 induced by IFN-gamma/LPS ; ( ii ) NF-kappaB signal pathway is essential for IFN-gamma/LPS to induce IL-12 mRNA expression ; ( iii ) by blocking the degradation of IkappaB, the PSI suppresses the IL-12 p40/p35 mRNA expression induced by LPS and IFN-gamma/LPS ; ( iv ) NF-kappaB signal may not be involved in the mechanism by which IFN-gamma enhanced the expression of the LPS induced IL-12 p40/p35 mRNA
Barber et al., J Immunol 1995 : A recent study demonstrated that LPS activated CAK without generating ceramide, suggesting that the LPS stimulation of cells mimics the second messenger function of ceramide