Xu et al., Eur J Pharmacol 2006
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Lipopolysaccharide (LPS) induced downregulation of pregnane X receptor and its target gene cyp3a11 has been well characterized in mouse liver ... In the present study, we investigated the effects of LPS on the expressions of pregnane X receptor and its target gene cyp3a11 in mouse intestine ... Correspondingly, oral administration with either N-acetylcysteine or ascorbic acid significantly attenuated LPS induced downregulation of intestinal pregnane X receptor and retinoid X receptor alphalpha ... Taken together, these results indicate that LPS suppresses the expressions of pregnane X receptor and its target gene cyp3a11 in mouse intestine ... LPS induced downregulation of pregnane X receptor and cyp3a11 in mouse intestine is mediated, at least in part, by oxidative stress
Li et al., Toxicol Lett 2008
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Correspondingly, a low dose LPS pretreatment attenuated LPS induced downregulation of pregnane X receptor (pxr) in fetal liver