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IRF6 — PRG2
Text-mined interactions from Literome
Fenton et al., Osteoarthritis Cartilage 2000
(Horse Diseases...) :
The addition of 25 mg/ml of glucosamine prevented the increase in nitric oxide production,
proteoglycan release and MMP activity
induced by
LPS or rhIL-1
Aota et al., Cell Tissue Res 2006
:
In articular chondrocytes,
LPS strongly
suppressed cell proliferation and
proteoglycan synthesis in a dose dependent manner and stimulated proteoglycan degradation ... Thus,
LPS suppressed
proteoglycan synthesis and stimulated proteoglycan degradation by articular chondrocytes and nucleus pulposus cells
Bobacz et al., Arthritis Rheum 2007
:
In murine and human articular chondrocytes, but not in chondrocytes derived from TLR-4 ( -/- ) mice, stimulation with
LPS resulted in a decrease in total
proteoglycan synthesis
Yeh et al., J Rheumatol 1995
:
IL-4 significantly reduced the cartilage
proteoglycan degradation
induced by IL-1 alpha, TNF-alpha, TNF-alpha plus IL-1 alpha, or
LPS ( 50 % inhibitory concentration, IC50 for IL-4 ranged from about 15 to 50 ng/ml )
Henrotin et al., J Rheumatol 1998
:
As well,
proteoglycan synthesis was profoundly
inhibited by IL-1beta and
LPS