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HSP90AA1 — MYC
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Teng et al., J Biol Chem 2004
(Cell Transformation, Neoplastic) :
Direct
activation of
HSP90A transcription by
c-Myc contributes to c-Myc induced transformation ... Here we show that
c-Myc directly
activates HSP90A transcription ...
c-Myc mediated induction of
HSP90A transcription occurs in different tissues, is independent of cell proliferation, and is mediated by a c-Myc binding site in the proximal promoter region of HSP90A gene
Li et al., Virology journal 2010
:
The regulation of
c-Myc mediated
HSP90 alpha promoter transactivation by HBx was evaluated through electrophoretic mobility shift analysis ( EMSA ) ... In addition, the luciferase activity of the HSP90alpha promoter analysis revealed that the HBx is directly involved in the
c-Myc mediated transcriptional activation of
HSP90alpha
Bansal et al., Blood 2010
(Leukemia, Myeloid) :
Furthermore,
Hsp90 inhibitors 17-AAG [ 17- ( allylamino ) -17-demethoxygeldanamycin ] and STA-9090 significantly reduced the growth of myeloid leukemia xenografts in vivo and effectively
down-regulated the expression of WT1 and its downstream target proteins,
c-Myc and Bcl-2
Regan et al., Int J Oncol 2011
(Neuroblastoma) :
It was found that
Hsp90 inhibition in neuroblastoma cell lines
resulted in significant growth suppression, a decrease in MYCN and
MYC expression, and an increase in the expression of p53