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GLI1 — WNT2
Pathways - manually collected, often from reviews:
-
KEGG Hedgehog signaling pathway:
GLI1/GLI2/GLI3
→
WNT1/WNT10A/WNT10B/WNT11/WNT16/WNT2/WNT2B/WNT3/WNT3A/WNT4/WNT5A/WNT5B/WNT6/WNT7A/WNT7B/WNT8A/WNT8B/WNT9A/WNT9B
(gene expression, expression)
-
KEGG Pathways in cancer:
GLI1/GLI2/GLI3
→
WNT1/WNT10A/WNT10B/WNT11/WNT16/WNT2/WNT2B/WNT3/WNT3A/WNT4/WNT5A/WNT5B/WNT6/WNT7A/WNT7B/WNT8A/WNT8B/WNT9A/WNT9B
(gene expression, expression)
-
KEGG Basal cell carcinoma:
GLI1/GLI2/GLI3
→
WNT1/WNT10A/WNT10B/WNT11/WNT16/WNT2/WNT2B/WNT3/WNT3A/WNT4/WNT5A/WNT5B/WNT6/WNT7A/WNT7B/WNT8A/WNT8B/WNT9A/WNT9B
(gene expression, expression)
Text-mined interactions from Literome
Akiyoshi et al., Gut 2006
(Colonic Neoplasms) :
To investigate whether expression of
Gli1 , a transactivator of Hh signalling, can
suppress Wnt signalling and inhibit proliferation of human colorectal cancer cells
Yanai et al., Cancer Lett 2008
(Stomach Neoplasms) :
When AGS gastric cancer cells, in which Wnt signaling was constitutively active, were used as a target cell line,
Gli1 overexpression
suppressed Wnt transcriptional activity, nuclear beta-catenin accumulation and proliferation of AGS cells
Nakamura et al., J Biol Chem 2013
(Wnt Signaling Pathway) :
WNT induces
GLI1 expression in a SULF2- and ß-CATENIN dependent manner