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HSPG2 — SST

Text-mined interactions from Literome

Rhie et al., Brain Res 2003 (Glioma...) : Thus, we conclude that activation of endogenous somatostatin receptors in NG108-15 cells induces the release of calcium from IP ( 3 ) -sensitive intracellular stores through PTX-sensitive G-protein coupled PLC
Kim et al., J Biol Chem 2012 : PDZ domain containing 1 ( PDZK1 ) protein regulates phospholipase C-ß3 (PLC-ß3)-specific activation of somatostatin by forming a ternary complex with PLC-ß3 and somatostatin receptors ... Through these interactions, PDZK1 assembles as a ternary complex with PLC-ß3 and SSTRs. Interestingly, the expression of PDZK1 and PLC-ß3, but not PLC-ß1, markedly potentiated SST induced PLC activation ... However, disruption of the ternary complex inhibited SST induced PLC activation, which suggests that PDZK1 mediated complex formation is required for the specific activation of PLC-ß3 by SST
Akbar et al., FEBS Lett 1994 : Activation of PLC by 1 microM somatostatin ( SRIF ) was in the order of : hSSTR5 > hSSTR2 > hSSTR3 > hSSTR4 > > hSSTR1