◀ Back to IRS1

IRS1 — RPTOR

Pathways - manually collected, often from reviews:

• NCI Pathway Database mTOR signaling pathway: mTORC1 complex (MTOR-MLST8-RPTOR) → IRS1 (IRS1) (modification, activates) Ozes et al., Proc Natl Acad Sci U S A 2001, Harrington et al., J Cell Biol 2004*, Um et al., Nature 2004*, Tremblay et al., Proc Natl Acad Sci U S A 2007*, Zhang et al., J Biol Chem 2008*
  Evidence: mutant phenotype, assay

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: IRS1 — RPTOR (physical association, affinity chromatography technology) Tzatsos et al., Mol Cell Biol 2006*
• IRef Biogrid Interaction: IRS1 — RPTOR (physical association, affinity chromatography technology) Tzatsos et al., J Biol Chem 2009*
• IRef Biogrid Interaction: IRS1 — RPTOR (direct interaction, pull down) Tzatsos et al., J Biol Chem 2009*
• IRef Hprd Interaction: RPTOR — IRS1 (in vitro) Tzatsos et al., Mol Cell Biol 2006*

Text-mined interactions from Literome

Tzatsos et al., Mol Cell Biol 2006 (Diabetes Mellitus, Type 2) : Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor dependent mTOR mediated insulin receptor substrate 1 phosphorylation
Shah et al., Mol Cell Biol 2006 (Tuberous Sclerosis) : Using two cell culture models of the familial hamartoma syndrome, tuberous sclerosis, we show here that Raptor-mTOR and S6K1 are required for phosphorylation of IRS1 at a subset of serine residues frequently associated with insulin resistance, including S307, S312, S527, S616, and S636 ( of human IRS1 ) ... These studies suggest that, through serine phosphorylation, Raptor-mTOR and S6K1 cell autonomously promote the depletion of IRS1 from specific intracellular pools in pathological states of insulin and IGF-I resistance and thus potentially in lesions associated with tuberous sclerosis
Tzatsos et al., J Biol Chem 2009 : Raptor binds the SAIN ( Shc and IRS-1 NPXY binding ) domain of insulin receptor substrate-1 (IRS-1) and regulates the phosphorylation of IRS-1 at Ser-636/639 by mTOR ... At the molecular level, Raptor binds the SAIN ( Shc and IRS-1 NPXY binding ) domain of IRS-1 and regulates the phosphorylation of IRS-1 at Ser-636/639 by mTOR
Geetha et al., J Endocrinol 2012 (Diabetes Mellitus, Type 2...) : These results indicate that PPP1R12A and PP1cd are new members of the insulin stimulated IRS1 signaling complex, and the interaction of PPP1R12A and PP1cd with IRS1 is dependent on Akt and mTOR/raptor activation
Xu et al., J Biol Chem 2012 : Recent work has implicated a role for cullin-RING E3 ubiquitin ligase 7 ( CRL7 ) in targeting IRS1 for mTORC1/S6K1 dependent degradation