◀ Back to TP53

BCHE — TP53

Text-mined interactions from Literome

Bruno et al., Cancer Cell 2006 : Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint
Passananti et al., Cell division 2007 : The DNA damage activated checkpoint kinases ATM and Chk2 interact with and phosphorylate Che-1, enhancing its accumulation and stability, and promoting Che-1 mediated transcription of p53-responsive genes and of p53 itself, as evidenced by microarray analysis
Bruno et al., Cancer Cell 2010 (Breast Neoplasms) : Che-1 is a RNA polymerase II binding protein involved in the regulation of gene transcription and, in response to DNA damage, promotes p53 transcription ... In this study, we investigated whether Che-1 regulates mutant p53 expression
Xu et al., Cell Mol Neurobiol 2013 (Brain Injuries) : One attractive biological function of Che-1 is promoting the transcription of p53 after DNA damage ; besides, it can also regulate cell cycle via interacting with retinoblastoma protein