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MMP2 — PDGFB

Pathways - manually collected, often from reviews:

• WikiPathways Angiogenesis: PDGFB/MMP9/VEGFA/MMP2/ANGPT1/FGF2 → PDGFB (activation)
• WikiPathways Angiogenesis: PDGFB/MMP9/VEGFA/MMP2/ANGPT1/FGF2 → MMP2/MMP9 (activation)

Text-mined interactions from Literome

Yang et al., Gastroenterology 2003 (Liver Cirrhosis) : Stimulation of HSCs with platelet derived growth factor (PDGF)-BB , transforming growth factor (TGF)-beta1, and/or epithelial growth factor (EGF) resulted in an increase in their migratory capacity and up-regulated matrix metalloproteinase (MMP)-2 activity
Risinger et al., J Biol Chem 2006 : Although both PDGF-BB and IGF-I stimulation resulted in decreased smooth muscle alpha-actin expression and increased matrix metalloproteinase (MMP)-2 expression, the response to IGF-I was significantly more rapid
Karakiulakis et al., J Biol Chem 2007 (Anoxia) : PDGF-BB inhibited the synthesis and secretion of all hypoxia dependent MMP via Erk1/2 mitogen activated protein ( MAP ) kinase activation
Liu et al., Neurol Res 2008 (Disease Models, Animal...) : So, PDGF-B may induce the expression of MMP for the degradation of collagen type III on the wall of the saccular aneurysms
Risinger et al., Am J Physiol Cell Physiol 2010 : The regulation of MMP-2 in response to PDGF-BB is complex and involves both stimulatory and inhibitory signaling pathways, resulting in a significant delay in upregulation