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CCND1 — LEP

Text-mined interactions from Literome

Saxena et al., FASEB J 2004 : Leptin resulted in a robust increase in cyclin D1 expression
Fombonne et al., Endocrinology 2007 : Leptin mediated decrease of cyclin A2 and increase of cyclin D1 expression : relevance for the control of prepubertal rat Leydig cell division and differentiation ... The analysis of G1/S-phase cyclins by quantitative ( real-time ) RT-PCR and Western blot points to the leptin induced decrease in cyclin A2 and subsequent increase in cyclin D1 expression that precedes a leptin triggered decrease in the number of prepubertal Leydig cells
Si et al., Experimental biology and medicine (Maywood, N.J.) 2007 : Furthermore, leptin induced cyclin D1 protein expression, which correlates well with HSC proliferation, was also significantly inhibited by leflunomide
Chen et al., Endocr Relat Cancer 2007 (Carcinoma, Hepatocellular...) : Leptin stimulated cyclin D1 promoter activity to increase cyclin D1 protein expression, which accelerated the cell cycle progression
Catalano et al., J Cell Physiol 2009 (Endometrial Neoplasms) : Mutagenesis studies, eletrophoretic mobility shift, and chromatin immunoprecipitation analysis revealed that signal transducers and activators of transcription 3 ( STAT3 ) and cyclic AMP-responsive element ( CRE ) binding protein motifs, within cyclin D1 promoter, were required for leptin induced cyclin D1 expression in Ishikawa endometrial cancer cells
Lam et al., Proc Natl Acad Sci U S A 2010 : We further show that leptin can induce Bcl-2 and cyclin D1 expression by two pathways, including the direct activation of their promoters and suppression of microRNAs ( miRNAs ) that target their putative 3'untranslated regions
Kim et al., Carcinogenesis 2011 (Breast Neoplasms...) : Furthermore, overexpression of constitutively active Stat3 imparted significant protection against BITC mediated inhibition of cyclin D1 transactivation, whereas RNA interference of Stat3 resulted in a significant increase in BITC mediated inhibition of cyclin D1 transactivation in the presence of leptin ... These results indicate that Stat3 plays an important role in BITC mediated inhibition of leptin induced cyclin D1 transactivation
Zheng et al., J Cancer Res Clin Oncol 2012 (Mammary Neoplasms, Experimental) : Leptin regulates cyclin D1 in luminal epithelial cells of mouse MMTV-Wnt-1 mammary tumors ... In vitro studies indicate that leptin induces expression of cyclin D1 , a cell-cycle control protein necessary for mammary tumor development
Li et al., PloS one 2012 : Pharmacological inhibition of JAK/STAT3, PI3K/Akt or MEK/ERK signaling by AG490, Wortmannin or U0126, respectively, reduced leptin induced cyclin D1 expression and NP cell proliferation ... Taken together, we show that leptin induces human NP cell cyclin D1 expression and proliferation via activation of JAK/STAT3, PI3K/Akt or MEK/ERK signaling
Chen et al., Int J Oncol 2013 (MAP Kinase Signaling System...) : Using western blot analysis, we found that leptin enhanced the expression of cyclin D1 and Mcl-1, which are important regulators of cell proliferation and the inhibition of apoptosis ... Our data demonstrate that leptin upregulates the expression of cyclin D1 and Mcl-1 to stimulate cell growth by activating the PI3K/Akt and MEK/ERK1/2 pathways in ovarian cancer